Adan A, Brutel de la Rivière A, Haas F, van Zalk A, de Nooij E
Department of Anaesthesiology, St. Antonius Hospital, Nieuwegein, The Netherlands.
Thorac Cardiovasc Surg. 1988 Feb;36(1):10-4. doi: 10.1055/s-2007-1020034.
In a randomised prospective study the efficacy of autotransfusion was investigated in two groups of 25 patients, a study group in which autologous blood was collected from the mediastinal tubes and retransfused, and a second, control group, in which only stored blood was used. In the study group, a reduction of 50% in the amount of stored blood required was observed. However, in two out of 25 patients the transfusion system could not be used due to clot formation in one of its components. From the total bloodloss per patient about 25% became available for autotransfusion. No significant differences between the two groups were found for hemoglobine, hematocrite, white blood count, platelets and fibrinogen level. Coagulation studies of the drain blood indicate that an active process of mediastinal clotting, followed by fibrinolysis occurs during the losing and collecting. The blood available for retransfusion contained a considerable amount of small-sized debris. It is concluded that autotransfusion of drain blood is not to be recommended for routine use.
在一项随机前瞻性研究中，对两组各25例患者的自体输血疗效进行了研究。一组为研究组，从纵隔引流管收集自体血并回输；另一组为对照组，仅使用库存血。在研究组中，观察到所需库存血量减少了50%。然而，25例患者中有2例因输血系统的一个组件形成凝块而无法使用该系统。每位患者的总失血量中约25%可用于自体输血。两组在血红蛋白、血细胞比容、白细胞计数、血小板和纤维蛋白原水平方面未发现显著差异。对引流血的凝血研究表明，在失血和采血过程中会发生纵隔内的主动凝血过程，随后是纤维蛋白溶解。可用于回输的血液中含有大量小尺寸碎片。得出的结论是，不建议常规使用引流血自体输血。
