Academic Psychiatry Department, Campus of Ageing and Vitality, Westgate Road, Newcastle-upon-Tyne, NE4 6BE, UK.
Psychol Med. 2022 Feb;52(3):467-475. doi: 10.1017/S003329172000210X. Epub 2020 Jun 29.
Cognitive deficits affect a significant proportion of patients with bipolar disorder (BD). Problems with sustained attention have been found independent of mood state and the causes are unclear. We aimed to investigate whether physical parameters such as activity levels, sleep, and body mass index (BMI) may be contributing factors.
Forty-six patients with BD and 42 controls completed a battery of neuropsychological tests and wore a triaxial accelerometer for 21 days which collected information on physical activity, sleep, and circadian rhythm. Ex-Gaussian analyses were used to characterise reaction time distributions. We used hierarchical regression analyses to examine whether physical activity, BMI, circadian rhythm, and sleep predicted variance in the performance of cognitive tasks.
Neither physical activity, BMI, nor circadian rhythm predicted significant variance on any of the cognitive tasks. However, the presence of a sleep abnormality significantly predicted a higher intra-individual variability of the reaction time distributions on the Attention Network Task.
This study suggests that there is an association between sleep abnormalities and cognition in BD, with little or no relationship with physical activity, BMI, and circadian rhythm.
认知缺陷影响了相当一部分双相情感障碍（BD）患者。已经发现，注意力持续时间的问题与情绪状态无关，其原因尚不清楚。我们旨在研究身体参数，如活动水平、睡眠和体重指数（BMI）是否可能是促成因素。
46 名 BD 患者和 42 名对照者完成了一系列神经心理学测试，并佩戴三轴加速度计 21 天，收集身体活动、睡眠和昼夜节律信息。使用外高斯分析来描述反应时间分布。我们使用分层回归分析来检查身体活动、BMI、昼夜节律和睡眠是否可以预测认知任务表现的差异。
无论是身体活动、BMI 还是昼夜节律都不能预测认知任务中的显著差异。然而，睡眠异常的存在显著预测了注意力网络任务中反应时间分布的个体内变异性更高。
这项研究表明，BD 中存在睡眠异常与认知之间的关联，而与身体活动、BMI 和昼夜节律的关系很小或没有关系。
