Dejaeger P, Van de Werf F, Vermylen J, De Geest H
Department of Cardiology, U.Z. Gasthuisberg, Leuven.
Acta Cardiol. 1988;43(1):61-5.
A 58-year old patient is reported who developed an ischaemic cerebrovascular accident 22 hours after successful thrombolysis with streptokinase for life-threatening pulmonary emboli. Despite effective thrombolysis, the plasma fibrinogen level rose during streptokinase administration and reached extremely high values 72 hours later. The mechanism of this unusual early and extreme rise of fibrinogen levels is unclear but it probably played a role in the pathogenesis of the cerebrovascular accident.
据报道,一名58岁患者在使用链激酶成功溶栓治疗危及生命的肺栓塞22小时后发生缺血性脑血管意外。尽管溶栓有效,但在使用链激酶期间血浆纤维蛋白原水平升高,并在72小时后达到极高值。纤维蛋白原水平这种异常的早期和极端升高的机制尚不清楚,但它可能在脑血管意外的发病机制中起了作用。