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Reversing immunosenescence for prevention of COVID-19.

作者信息

Brooke Robert T, Fahy Gregory M

机构信息

Intervene Immune, Inc., Torrance, CA 90502, USA.

出版信息

Aging (Albany NY). 2020 Jun 28;12(12):11161-11162. doi: 10.18632/aging.103636.

DOI:10.18632/aging.103636
PMID:32597792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7343453/
Abstract
摘要

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本文引用的文献

1
Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals.COVID-19 疾病患者和未接触者体内针对 SARS-CoV-2 冠状病毒的 T 细胞反应的靶标。
Cell. 2020 Jun 25;181(7):1489-1501.e15. doi: 10.1016/j.cell.2020.05.015. Epub 2020 May 20.
2
Why does COVID-19 disproportionately affect older people?为什么新冠病毒对老年人的影响尤为严重？
Aging (Albany NY). 2020 May 29;12(10):9959-9981. doi: 10.18632/aging.103344.
3
Thymosin Alpha 1 Reduces the Mortality of Severe Coronavirus Disease 2019 by Restoration of Lymphocytopenia and Reversion of Exhausted T Cells.胸腺素 α1 通过恢复淋巴细胞减少症和逆转耗竭 T 细胞来降低严重 COVID-19 的死亡率。
Clin Infect Dis. 2020 Nov 19;71(16):2150-2157. doi: 10.1093/cid/ciaa630.
4
Functional exhaustion of antiviral lymphocytes in COVID-19 patients.新冠病毒肺炎患者抗病毒淋巴细胞的功能耗竭
Cell Mol Immunol. 2020 May;17(5):533-535. doi: 10.1038/s41423-020-0402-2. Epub 2020 Mar 19.
5
Reversal of epigenetic aging and immunosenescent trends in humans.人类表观遗传衰老和免疫衰老趋势的逆转。
Aging Cell. 2019 Dec;18(6):e13028. doi: 10.1111/acel.13028. Epub 2019 Sep 8.
6
DNA methylation-based biomarkers and the epigenetic clock theory of ageing.基于 DNA 甲基化的生物标志物和衰老的表观遗传时钟理论。
Nat Rev Genet. 2018 Jun;19(6):371-384. doi: 10.1038/s41576-018-0004-3.
7
Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection.针对严重急性呼吸综合征冠状病毒的记忆性T细胞反应在感染后持续长达11年。
Vaccine. 2016 Apr 12;34(17):2008-14. doi: 10.1016/j.vaccine.2016.02.063. Epub 2016 Mar 5.
8
Growth hormone enhances thymic function in HIV-1-infected adults.生长激素可增强HIV-1感染成人的胸腺功能。
J Clin Invest. 2008 Mar;118(3):1085-98. doi: 10.1172/JCI32830.