Dun N J, Mo N
Department of Pharmacology, Loyola University Stritch School of Medicine, Maywood, IL 60153.
Neurosci Lett. 1988 Apr 22;87(1-2):157-62. doi: 10.1016/0304-3940(88)90162-0.
Pressure application of calcitonin gene-related peptide (CGRP) evoked in a population of coeliac neurons three types of response: a fast, a slow and a biphasic depolarization consisting of the first two responses in sequence. The fast and slow depolarization exhibited distinct electrophysiological and pharmacological characteristics, suggesting that these two responses may be mediated by separate CGRP receptors. Moreover, our results show that CGRP is one of the few peptides known to date that cause a fast, sodium-sensitive depolarization.
降钙素基因相关肽（CGRP）施加压力在一群腹腔神经节神经元中引发了三种类型的反应：快速、缓慢和双相去极化，双相去极化依次由前两种反应组成。快速和缓慢去极化表现出不同的电生理和药理学特征，表明这两种反应可能由不同的CGRP受体介导。此外，我们的结果表明，CGRP是迄今为止已知的少数能引起快速、钠敏感去极化的肽之一。
