Laboratório interdisciplinar de materiais avançados (LIMAV), Programa de Pós-Graduação em Ciência e Engenharia dos Materiais, Universidade Federal do Piauí - UFPI, Teresina, PI, Brazil.
Instituto Federal de Educação, Ciência e Tecnologia do Piauí - IFPI, 64760-000, Campus São João do Piauí, PI, Brazil.
Mater Sci Eng C Mater Biol Appl. 2020 Oct;115:111051. doi: 10.1016/j.msec.2020.111051. Epub 2020 May 5.
Nano-heterostructures of titanate nanotubes were synthesized and they revealed a complex structure with the formation of TiO (anatase), CeO, AgO and metallic silver nanoparticles on the outer walls and intercalation of Ce and Ag into the interlayer spaces of the nanotubes by microwave-assisted hydrothermal process and subjected to ion exchange reactions. To the best of our knowledge, this is the first reported silver and cerium co-exchanged titanate nanotubes for bio-applications. The co-ion exchange processes preserved the original tubular structure of titanate nanotubes with significant changes of the superficial as well as interlamellar environment. This study opens up possibility of synthesizing complex, functional nano-heterostructure with the scope of modification of the final structure, especially the amount and oxidation state of the intercalated cation (Ce, Ce and Ag) as well as the quantity and variety of the decorating nanoparticles (CeO, AgO or metallic Ag). The interplay of which, in turn, can lead to important biological properties and applications, owing to their ion-liberation capacity. The samples were tested in antibacterial activity with two different kind of bacteria (gram positive and negative), cell cytotoxicity and adhesion, and it was found that the nano-heterostructure formed shows high antibacterial activity with low cytotoxicity and high cell adhesion, which makes it a promising material for further health applications.
采用微波辅助水热法合成了钛酸盐纳米管的纳米杂化结构，在其外壁上形成了 TiO（锐钛矿）、CeO、AgO 和金属银纳米粒子，同时通过离子交换反应将 Ce 和 Ag 插入纳米管的层间空间。据我们所知，这是首次报道用于生物应用的银和铈共交换钛酸盐纳米管。共离子交换过程保留了钛酸盐纳米管的原始管状结构，同时对表面和层间环境发生了显著变化。这项研究为合成复杂的功能纳米杂化结构开辟了可能性，可对最终结构进行修饰，特别是对插层阳离子（Ce、Ce 和 Ag）的数量和氧化态以及修饰纳米粒子（CeO、AgO 或金属 Ag）的数量和种类进行修饰。这些因素的相互作用，又会导致重要的生物学特性和应用，这要归因于它们的离子释放能力。对两种不同类型的细菌（革兰氏阳性菌和革兰氏阴性菌）进行了抗菌活性、细胞毒性和黏附性测试，结果表明，所形成的纳米杂化结构具有高抗菌活性、低细胞毒性和高细胞黏附性，这使其成为进一步健康应用的有前途的材料。
