Chakraborty C, Tawfik O W, Dey S K
Department of Gynecology & Obstetrics, University of Kansas Medical Center, Kansas City 66103.
Biochem Biophys Res Commun. 1988 Jun 16;153(2):564-9. doi: 10.1016/s0006-291x(88)81132-x.
The profile of epidermal growth factor (EGF) binding to uterine membranes of rats on Day 1 through Day 7 of pregnancy was studied. The binding was lowest on Day 1 and increased gradually through the pre- and postimplantation periods. Binding affinity of the Day 7 uterine membranes was considerably higher than that of the Day 1. Apparent affinity constants (Ka) of Day 1 and Day 7 membranes were 0.29 X 10(-8) M and 1.03 X 10(-8) M respectively. To our knowledge, this is the first report of the modulation of EGF binding to uterine membranes by progesterone-estrogen interaction during early pregnancy.
研究了妊娠第1天至第7天大鼠子宫内膜生长因子（EGF）结合情况。第1天结合量最低，在着床前和着床后阶段逐渐增加。第7天子宫内膜的结合亲和力明显高于第1天。第1天和第7天膜的表观亲和常数（Ka）分别为0.29×10⁻⁸ M和1.03×10⁻⁸ M。据我们所知，这是关于妊娠早期孕酮-雌激素相互作用对EGF与子宫内膜结合的调节作用的首次报道。
