工程细胞外囊泡作为 microRNA 递送的有前途的工具用于骨关节炎治疗。
Engineered-extracellular vesicles as an optimistic tool for microRNA delivery for osteoarthritis treatment.
机构信息
Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Department of Developmental Biology, University of Science and Culture, Tehran, Iran.
出版信息
Cell Mol Life Sci. 2021 Jan;78(1):79-91. doi: 10.1007/s00018-020-03585-w. Epub 2020 Jun 29.
Abstract
Worldwide, osteoarthritis (OA) is one of the most common chronic diseases. In OA, profiling gene expression changes occur and cartilage tissue homeostasis is lost. Suggestions for OA treatment include regulation of gene expressions via the use of microRNAs (miRNAs). However, problems exist with the use of miRNAs, the most important of which is the delivery of sufficient amounts of effective miRNAs to save cartilage tissue. The engineering of extracellular vesicles (EVs) with the use of advanced techniques would be an efficient OA treatment. Therefore, we discuss the importance of miRNAs in terms of cartilage tissue regeneration and review recent advances in production of enriched EVs and miRNA delivery by EVs for future clinical applications.
摘要
在全球范围内，骨关节炎（OA）是最常见的慢性疾病之一。在 OA 中，会出现基因表达谱的变化，软骨组织的动态平衡会丧失。OA 的治疗建议包括通过使用 microRNAs（miRNAs）来调节基因表达。然而，miRNAs 的使用存在问题，其中最重要的是输送足够数量的有效 miRNAs 以保存软骨组织。利用先进技术工程化细胞外囊泡（EVs）将是一种有效的 OA 治疗方法。因此，我们讨论了 miRNAs 在软骨组织再生方面的重要性，并回顾了最近在生产富含 EVs 和 EV 介导的 miRNA 递送上的进展，以期未来的临床应用。
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