Core-satellite surface imprinting polymer-based pipette tip solid-phase extraction for the colorimetric determination of pyrethroid metabolite.

A core-satellite-structured surface molecularly imprinted polymer has been synthesized for the enrichment of 3-phenoxybenzaldehyde by pipette tip solid-phase extraction (SPE). In a typical sol-gel process, two silane reagents as functional monomers and 3-phenoxybenzoic acid as the dummy template, the surface imprinting layer was coated on the core-satellite silica microsphere, which formed the core-satellite-structured molecularly imprinted polymer (CSMIP). Compared to the silica-based core-shell ones, this CS-MIP exhibits a stunning surface area (142 m g) in micrometer size and also overcomes the aggregation trends of core-shell structure in nanoscale. Taking potassium permanganate solution as oxidizer and indicator, the adsorbed 3-phenoxybenzaldehyde can be a quantitatively determined through redox reaction after elution. The value of maximum adsorption capacity and imprinting factor of CS-MIP were calculated to be 87.5 μg mg and 2.13, respectively. These CS-MIPs were packed into commercial pipette tip as the sorbent to concentrate 3-phenoxybenzaldehyde. Under the optimum condition, a liner relationship was achieved in the range 0.200 to 1.00 μg mL and the limit of detection was 81 ng mL. Moreover, this customized SPE device exhibits good adsorption capability after six sequential adsorption-desorption cycles, and the high recovery range of 92.2~99.7% of spiked tap water assay demonstrated its potential application for real sample analysis. Graphical abstract Schematic presentation of core-satellite molecularly imprinted polymer preparation strategy and customized pipette tip solid-phase extraction device.