Division of Gastroenterology and Hepatology, Department of Medicine, National University Hospital, Singapore.
Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
J Gastroenterol Hepatol. 2021 Feb;36(2):413-420. doi: 10.1111/jgh.15165. Epub 2020 Jul 9.
Singapore is a multi-ethnic country that has undergone rapid development over the last few decades, with increasing influence of western culture, and faces an aging population. Previously, a varying prevalence of colonic diverticulosis (CD) was reported by a few small studies. This study aims to evaluate the prevalence of CD in Singapore and identify associations with common gastrointestinal symptoms and risk factors.
We reviewed retrospective data of 20 395 consecutive colonoscopies performed from 2006 to 2016 for presence of CD and indications of screening, diarrhea, constipation, and abdominal pain.
The prevalence of CD progressively increased from 2006 to 2016 (14.9% vs 23.9%, adjusted trend < 0.001), with an overall prevalence of 19.6%. Patients with CD were older and had higher body mass index (BMI). CD was significantly more prevalent in Chinese compared with Malay and Indian races (20.5% vs 18.9% vs 15.5%, P < 0.05), and in male patients compared with female patients (21.5% vs 17.6%, P < 0.05). Right-sided CD was more common than left-sided or pan diverticulosis (16.2% vs 8.3% vs 4.8%, P < 0.05). Age [odds ratio (OR), 1.060; 95% confidence interval (CI), 1.052-1.068], BMI (OR, 1.051; 95% CI, 1.028-1.075), male gender (OR, 1.317; 95% CI, 1.084-1.600), and abdominal pain (OR, 1.409; 95% CI, 1.168-1.699) were positively associated, while constipation (OR, 0.566; 95% CI, 0.452-0.709) was negatively associated with CD.
The prevalence of CD in Singapore has progressively increased over the last decade and is associated with older age, higher BMI, and abdominal pain. These findings may provide insights for healthcare resource planning in the region.
新加坡是一个多民族国家，在过去几十年经历了快速发展，西方文化的影响日益增强，同时也面临着人口老龄化的问题。此前，少数几项小型研究报告了不同的结肠憩室病（CD）患病率。本研究旨在评估新加坡 CD 的患病率，并确定其与常见胃肠道症状和危险因素的关联。
我们回顾了 2006 年至 2016 年期间 20395 例连续结肠镜检查的回顾性数据，以评估 CD 的存在和筛查、腹泻、便秘和腹痛的指征。
CD 的患病率从 2006 年到 2016 年逐渐增加（14.9%比 23.9%，调整趋势<0.001），总体患病率为 19.6%。患有 CD 的患者年龄较大，体重指数（BMI）较高。与马来族和印度族相比，华人中 CD 的患病率明显更高（20.5%比 18.9%比 15.5%，P<0.05），男性患者中 CD 的患病率也高于女性（21.5%比 17.6%，P<0.05）。右侧 CD 比左侧或全结肠憩室病更为常见（16.2%比 8.3%比 4.8%，P<0.05）。年龄[比值比（OR），1.060；95%置信区间（CI），1.052-1.068]、BMI（OR，1.051；95%CI，1.028-1.075）、男性（OR，1.317；95%CI，1.084-1.600）和腹痛（OR，1.409；95%CI，1.168-1.699）与 CD 呈正相关，而便秘（OR，0.566；95%CI，0.452-0.709）与 CD 呈负相关。
在过去十年中，新加坡 CD 的患病率呈上升趋势，与年龄较大、BMI 较高和腹痛有关。这些发现可能为该地区的医疗保健资源规划提供参考。
