蓝莓提取物对不同来源的一组肿瘤细胞系的抗增殖作用。
Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin.
机构信息
Laboratory of Molecular Oncology, Science and Technology Department, National University of Quilmes, Roque Saenz Peña 352, B1876 Bernal, Buenos Aires, Argentina.
出版信息
Exp Oncol. 2020 Jun;42(2):101-108. doi: 10.32471/exp-oncology.2312-8852.vol-42-no-2.14766.
BACKGROUND
Blueberries are among the fruits with the highest antioxidant activity and have been recognized by their health promoting properties.
AIM
In vitro study of the anti-proliferative effects of a blueberry extract on a panel of cancer cells from different origin.
MATERIALS AND METHODS
A blueberry extract was produced using ethanol as extracting solvent. The anti-proliferative activity of the extract was evaluated against seven tumor cell lines. The properties of blueberry extract to decrease cell adhesion and migration were also investigated.
RESULTS
Blueberry extract showed a dose-dependent inhibitory effect on cell proliferation for all cell lines. Non-cytotoxic concentrations of the extract decreased cell adhesion in five of seven cell lines studied and inhibited the migration of MDA-MB-231 and PC-3 tumor cells.
CONCLUSION
This work provides additional evidence regarding the ability of blueberry extract to inhibit the growth and decrease cell adhesion and migration of different cancer cell lines in vitro.
背景
蓝莓是抗氧化活性最高的水果之一，其具有促进健康的特性已得到认可。
目的
研究蓝莓提取物对不同来源的一组癌细胞的体外抗增殖作用。
材料和方法
使用乙醇作为提取溶剂生产蓝莓提取物。评估提取物对七种肿瘤细胞系的抗增殖活性。还研究了蓝莓提取物降低细胞黏附和迁移的特性。
结果
蓝莓提取物对所有细胞系的细胞增殖均表现出剂量依赖性抑制作用。非细胞毒性浓度的提取物降低了所研究的七种细胞系中的五种细胞黏附，并抑制了 MDA-MB-231 和 PC-3 肿瘤细胞的迁移。
结论
这项工作为蓝莓提取物抑制不同体外癌细胞系生长以及降低细胞黏附和迁移的能力提供了额外的证据。
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