Kairento A L, Livni E, Mattila S, Harjula A, Porkka L, Lindroth L, Elmaleh D R
Meilahti Hospital, University Central Hospital, Helsinki, Finland.
Int J Rad Appl Instrum B. 1988;15(3):333-8. doi: 10.1016/0883-2897(88)90115-8.
The concept of using beta-methyl-branched long-chain fatty acids for assessment of myocardial fatty acid uptake and perfusion was extended to the use of radioiodinated fatty acid with stabilization of iodine on the omega-phenyl ring. Beagle dogs were injected with thallium-201 and imaged 15 min after injection. The next day the dogs were infarcted by occluding the LAD, and 2 h later they were injected with [123I]14-p-iodophenyl-beta-methyltetradecanoic acid [123I]BMTDA and imaged for 90 min using a gated SPECT procedure. Maximum uptake of BMTDA in the heart was reached 2 min post injection and the activity level remained constant in the heart during the imaging period. The activity ratio of target to nontarget areas in the tomographic slices was significantly better for the BMTDA imaging compared to 201Tl (P greater than 0.01).
使用β-甲基支链长链脂肪酸评估心肌脂肪酸摄取和灌注的概念扩展到使用在ω-苯环上稳定碘的放射性碘化脂肪酸。给比格犬注射铊-201，并在注射后15分钟进行成像。第二天，通过闭塞左前降支使犬发生梗死，2小时后给它们注射[123I]14-p-碘苯基-β-甲基十四烷酸[123I]BMTDA，并使用门控单光子发射计算机断层扫描（SPECT）程序进行90分钟成像。注射后2分钟达到BMTDA在心脏中的最大摄取量，并且在成像期间心脏中的活性水平保持恒定。与铊-201相比，BMTDA成像在断层切片中靶区与非靶区的活性比明显更好（P大于0.01）。
