Ferretti J J, Lu W, Liu M B
Am J Clin Pathol. 1977 Jun;67(6):526-7. doi: 10.1093/ajcp/67.6.526.
Seven compounds commonly used as chromagens for the detection of hemoglobin and its derivatives have been assayed for mutagenicity employing the Salmonella/mammalian microsome test. Three of these compounds, benzidine, o-dianisidine, and o-tolidine, were shown to be mutagenic. Since benzidine and o-tolidine are already known to be carcinogens, there is a high probability that o-dianisidine will also prove to be a carcinogen. Four compounds tested with this system, o-anisidine, diphenylamine, guaicol, and o-toluidine, were not mutagenic.
已使用沙门氏菌/哺乳动物微粒体试验对七种通常用作检测血红蛋白及其衍生物的显色剂的化合物进行了致突变性测定。其中三种化合物，联苯胺、邻联茴香胺和邻联甲苯胺，显示具有致突变性。由于联苯胺和邻联甲苯胺已被确认为致癌物，邻联茴香胺也极有可能被证明是一种致癌物。用该系统测试的四种化合物，邻茴香胺、二苯胺、愈创木酚和邻甲苯胺，没有致突变性。
