AcSIR and Natural Product Microbes, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, Jammu and Kashmir.
Department of Chemistry, University of Kashmir, Srinagar 190006, Jammu and Kashmir.
Org Lett. 2020 Jul 17;22(14):5661-5665. doi: 10.1021/acs.orglett.0c02055. Epub 2020 Jun 30.
A photoredox-mediated protocol for the synthesis of α-alkoxy-β-ketosulfoxides and α,β-dialkoxysulfoxides using alkynes, thiol, and alcohols is reported. This work presents a rare single-step synthesis of α-substituted sulfoxides, involving tandem introduction of a thiol and alcohol as a key enabling advancement. Furthermore, the method can be easily employed to access vinyl sulfoxides and β-ketosulfoxides.
本文报道了一种通过光氧化还原介导的方法，使用炔烃、硫醇和醇合成α-烷氧基-β-酮亚砜和α,β-二烷氧基亚砜的方法。这项工作展示了一种罕见的α-取代亚砜的单步合成方法，其中硫醇和醇的串联引入是关键的促进步骤。此外，该方法还可用于合成乙烯基亚砜和β-酮亚砜。
