发育过程中的血浆免疫反应性胰蛋白酶（原）水平。

Plasma immunoreactive-trypsin(ogen) levels during development.

作者信息

Levine J J, Udall J N, Bloch K J, Hanson D G, James B C, Walker W A

机构信息

Department of Pediatric Gastroenterology, Schneider Children's Hospital, State University of New York at Stony Brook, New Hyde Park 11042.

出版信息

J Pediatr Gastroenterol Nutr. 1988 May-Jun;7(3):406-10. doi: 10.1097/00005176-198805000-00016.

DOI:10.1097/00005176-198805000-00016

PMID:3260281

Abstract

We previously showed that the uptake of intact trypsin from the intestine of suckling animals was greater than that of weaned animals. To extend these studies, we measured plasma cationic immunoreactive-trypsin(ogen) in human subjects aged 3 days to 43 years. In agreement with the observation of other investigators, we found that the concentration of cationic immunoreactive-trypsin(ogen) was significantly increased in 3-day-old infants compared with other age groups. None of the cationic immunoreactive-trypsin in adult samples was bound to alpha 1-antitrypsin, whereas 28% of cationic immunoreactive-trypsin in infant samples was bound to alpha 1-anti-trypsin.

摘要

我们之前的研究表明，哺乳类动物肠道中完整胰蛋白酶的摄取量高于断奶动物。为拓展这些研究，我们测定了年龄在3天至43岁的人类受试者血浆中阳离子免疫反应性胰蛋白酶（原）的含量。与其他研究者的观察结果一致，我们发现，与其他年龄组相比，3日龄婴儿的阳离子免疫反应性胰蛋白酶（原）浓度显著升高。成人样本中，阳离子免疫反应性胰蛋白酶均未与α1抗胰蛋白酶结合，而婴儿样本中有28%的阳离子免疫反应性胰蛋白酶与α1抗胰蛋白酶结合。