血清CCL2水平可预测胰腺癌患者的预后。
Serum level of CCL2 predicts outcome of patients with pancreatic cancer.
作者信息
Feng L, Qi Q, Wang P, Chen H, Chen Z, Meng Z, Liu L
机构信息
Departments of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Department of Oncology, Shanghai Medical College, Shanghai 200032, China.
出版信息
Acta Gastroenterol Belg. 2020 Apr-Jun;83(2):295-299.
BACKGROUND
Pancreatic cancer is one of the most deadly cancers worldwide with a five-year survival rate of less than 5%. Chronic pancreatitis showed increased risk to develop pancreatic cancer, in which chronic inflammation of the pancreas may play a critical role. Cytokines play an indispensable role in inflammatory reaction and tumorigenesis. The purpose of this study was to determine whether cytokines were associated with survival and poor prognosis of pancreatic cancer.
METHODS
In this study, we examined levels of some important cytokines in the serum of 68 patients with pancreatic cancer, including CCL2, CCL17, CXCL-1, CXCL-5, G-CSF, GM-CSF, TGF-β and IFN-γ.
RESULTS
We found that high level of serum CCL2 was strongly associated with poor survival and prognosis, but no significant association with other clinicopathological features, including gender, age, location and TNM staging. For other cytokines, no significant correlation with poor survival and prognosis was found.
CONCLUSION
Our results suggest that serum level of CCL2 may serve as a potential marker for predicting the outcome of patients with pancreatic cancer.
背景
胰腺癌是全球最致命的癌症之一，五年生存率低于5%。慢性胰腺炎患胰腺癌的风险增加，其中胰腺的慢性炎症可能起关键作用。细胞因子在炎症反应和肿瘤发生中起不可或缺的作用。本研究的目的是确定细胞因子是否与胰腺癌的生存及不良预后相关。
方法
在本研究中，我们检测了68例胰腺癌患者血清中一些重要细胞因子的水平，包括CCL2、CCL17、CXCL-1、CXCL-5、G-CSF、GM-CSF、TGF-β和IFN-γ。
结果
我们发现血清CCL2水平高与生存及预后不良密切相关，但与其他临床病理特征，包括性别、年龄、部位和TNM分期无显著关联。对于其他细胞因子，未发现与生存及预后不良有显著相关性。
结论
我们的结果表明，血清CCL2水平可能作为预测胰腺癌患者预后的潜在标志物。
Zotero 插件