Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Recent Pat Anticancer Drug Discov. 2020;15(2):143-153. doi: 10.2174/1574892815666200630103626.
As one of the most commonly diagnosed cancers among men and women, Colorectal Cancer (CRC) leads to high rates of morbidity and mortality across the globe. Recent anti- CRC therapies are now targeting specific signaling pathways involved in colorectal carcinogenesis. Ubiquitin Proteasome System (UPS) and autophagy are two main protein quality control systems, which play major roles in the carcinogenesis of colorectal cancer. A balanced function of these two pathways is necessary for the regulation of cell proliferation and cell death.
In this systematic review, we discuss the available evidence regarding the roles of autophagy and ubiquitination in progression and inhibition of CRC.
The search terms "colorectal cancer" or "colon cancer" or "colorectal carcinoma" or "colon carcinoma" in combination with "ubiquitin proteasome" and "autophagy" were searched in PubMed, Web of Science, and Scopus databases, and also Google Patents (https://patents.google .com) from January 2000 to Feb 2020.
The most important factors involved in UPS and autophagy have been investigated. There are many important factors involved in UPS and autophagy but this systematic review shows the studies that have mostly focused on the role of ATG, 20s proteasome and mTOR in CRC, and the more important factors such as ATG8, FIP200, and TIGAR factors that are effective in the regulation of autophagy in CRC cells have not been yet investigated.
The most important factors involved in UPS and autophagy such as ATG, 20s proteasome and mTOR, ATG8, FIP200, and TIGAR can be considered in drug therapy for controlling or activating autophagy.
结直肠癌（CRC）是男性和女性中最常见的癌症之一，在全球范围内导致高发病率和死亡率。目前的抗 CRC 治疗方法针对的是参与结直肠发生的特定信号通路。泛素蛋白酶体系统（UPS）和自噬是两种主要的蛋白质质量控制系统，它们在结直肠癌的发生中起着重要作用。这两种途径的平衡功能对于调节细胞增殖和细胞死亡是必要的。
在本系统评价中，我们讨论了自噬和泛素化在 CRC 进展和抑制中的作用的现有证据。
在 PubMed、Web of Science 和 Scopus 数据库中搜索“结直肠癌”或“结肠癌”或“结直肠腺癌”或“结肠癌”与“泛素蛋白酶体”和“自噬”相结合的检索词，并在 Google Patents（https://patents.google.com）上从 2000 年 1 月到 2020 年 2 月进行搜索。
已经研究了 UPS 和自噬中涉及的最重要因素。UPS 和自噬涉及许多重要因素，但本系统评价显示，大多数研究主要集中在 ATG、20s 蛋白酶体和 mTOR 在 CRC 中的作用，以及在 CRC 细胞中调节自噬的更重要因素，如 ATG8、FIP200 和 TIGAR 因素尚未得到研究。
UPS 和自噬中涉及的最重要因素，如 ATG、20s 蛋白酶体和 mTOR、ATG8、FIP200 和 TIGAR，可以考虑用于控制或激活自噬的药物治疗。
