University of California, San Francisco, USA.
Maxim Healthcare Services, Sacramento, California, USA.
Cutis. 2020 May;105(5):251-254.
Aminolevulinic acid (ALA) photodynamic therapy (PDT) is a preferred method for treatment of multiple actinic keratoses (AKs) in broad skin areas (referred to as field cancerization). Pretreatment with CO2 laser ablative fractional resurfacing (AFR) may increase the efficacy of PDT. This study compared the effect and durability of CO2 laser AFR-assisted ALA-PDT vs ALA-PDT alone in the treatment of AKs and nonmelanoma skin cancers (NMSCs) at various body locations. In this randomized, split-side study, 19 patients had 1 side pretreated with AFR before treatment of both sides with ALA-PDT. Results indicated that pretreatment with AFR provided superior clearance of AKs and thin NMSCs at 6 months compared to ALA-PDT alone.
氨基酮戊酸（ALA）光动力疗法（PDT）是治疗大面积多形性日光性角化病（AK）（亦称区域性癌化）的首选方法。二氧化碳激光消融性微剥脱术（AFR）预处理可能会提高 PDT 的疗效。本研究比较了 CO2 激光 AFR 辅助 ALA-PDT 与单纯 ALA-PDT 治疗不同部位 AK 和非黑素细胞皮肤癌（NMSC）的效果和持久性。在这项随机、双侧分拆研究中，19 例患者一侧用 AFR 预处理，然后两侧均用 ALA-PDT 治疗。结果表明，与单纯 ALA-PDT 相比，6 个月时 AFR 预处理可显著提高 AK 和薄型 NMSC 的清除率。
