From the Fellowship Program Minimally Invasive Gynecologic Surgery, Las Vegas Minimally Invasive Surgery/University of Nevada Las Vegas.
University of Nevada Las Vegas School of Medicine, Las Vegas.
Female Pelvic Med Reconstr Surg. 2021 Feb 1;27(2):e282-e289. doi: 10.1097/SPV.0000000000000903.
To conduct a systematic review and meta-analysis to estimate the prevalence of occult uterine malignancy of any subtype specifically at the time of hysterectomy for pelvic organ prolapse (POP).
We primarily used MEDLINE to access existing literature. The search terms used were "occult malignancy" or "occult uterine pathology" paired with "morcellation" or "hysterectomy." Our cutoff date for articles was March 25, 2019. We further narrowed articles down based on whether they included data on occult malignancy at time of hysterectomy specifically for POP.
Our search yielded a total of 233 journal articles, of which 53 met the criteria for a full-text review. Eight studies provided specific data on occult uterine malignancy among women undergoing surgery for POP and formed the basis for this meta-analysis. Among the 8 studies examined, the total number of patients combined was 35,880, and there were 144 total occult uterine malignancies. There were 7 case series and 1 population-based study included. The pooled prevalence of occult uterine malignancy at the time of hysterectomy for POP was 0.22% (95% confidence interval, 0.11%-0.35%]. There was very little heterogeneity observed across the 8 studies (I2 = 12.06%, Q χ2[7] = 7.96, P = 0.336).
The pooled prevalence of occult uterine malignancy, of any subtype, at the time of surgery for POP specifically is 0.22% based on meta-analysis of existing studies. Surgeons can use this statistic as part of the preoperative counseling of patients with POP before hysterectomy.
系统回顾和荟萃分析，以评估特定于盆腔器官脱垂（POP）子宫切除术时任何亚型隐匿性子宫恶性肿瘤的患病率。
我们主要使用 MEDLINE 访问现有文献。使用的搜索词是“隐匿性恶性肿瘤”或“隐匿性子宫病理学”，与“切碎术”或“子宫切除术”配对。我们的文章截止日期为 2019 年 3 月 25 日。我们进一步根据文章是否包含特定于 POP 子宫切除术时隐匿性恶性肿瘤的数据来缩小文章范围。
我们的搜索共产生了 233 篇期刊文章，其中 53 篇符合全文审查标准。8 项研究提供了接受 POP 手术的女性隐匿性子宫恶性肿瘤的具体数据，并构成了本次荟萃分析的基础。在检查的 8 项研究中，总患者数为 35880 例，总隐匿性子宫恶性肿瘤为 144 例。其中包括 7 项病例系列研究和 1 项基于人群的研究。POP 子宫切除术时隐匿性子宫恶性肿瘤的总患病率为 0.22%（95%置信区间，0.11%-0.35%）。8 项研究之间的异质性很小（I2 = 12.06%，Q χ2[7] = 7.96，P = 0.336）。
基于对现有研究的荟萃分析，特定于 POP 手术时任何亚型隐匿性子宫恶性肿瘤的总患病率为 0.22%。外科医生可以在 POP 子宫切除术前为患者提供咨询时使用该统计数据。
