Division of Neonatology, Department of Pediatrics, Einstein Medical Center Montgomery, CHOP Newborn Care Network, East Norriton, Pennsylvania.
Department of Pediatrics, Christiana Care Health System, Newark, Delaware.
Am J Perinatol. 2021 Dec;38(14):1488-1493. doi: 10.1055/s-0040-1713754. Epub 2020 Jun 30.
This study aimed to determine if formula selection, low lactose versus standard term formula, has an effect on outcomes with a comparison to breastfed infants.
Retrospective cohort study of neonates ≥35 weeks gestation born with Neonatal Abstinence Syndrome (NAS) was conducted from July 2014 to November 2016. Primary outcomes included length of pharmacologic treatment (LOT), and length of stay (LOS), and weight change per day comparing term standard and low lactose formula majority feeding infants with secondary outcomes comparing breast fed majority feeding infants.
After investigating feeding methods for 249 NAS infants, a direct comparison of formula groups showed no differences in LOS (3, 95% confidence interval [CI]: -1.1 to 7 days), LOT (3.9, 95% CI: -0.4 to 8.1 days), or weight change per day (-2.4, 95% CI: -11.7 to 6.9 g/day). Breastfeeding improved LOT by 6.9 (95% CI: 3.4-10.5) and 10.8 days (95% CI: 5.9-15.6) and LOS by 7.4 (95% CI: 4.1-10.7) and 10.3 (95% CI: 5.8-14.9) days all reaching significance, in comparison to term and low lactose formula groups, respectively. Weight change per day was greater in the breast versus formula feeding groups when compared individually.
We detected no benefit to low lactose formula in NAS infants. Breastfeeding is associated with clinical reduction in LOS and LOT but is associated with increased weight loss.
· Best formula choice for a neonatal abstinence syndrome (NAS) infant is unknown.. · Many NAS moms cannot breastfeed.. · Low lactose formula has no impact on NAS outcomes..
本研究旨在确定配方选择（低乳糖配方与标准配方）是否会对患有新生儿戒断综合征（NAS）的婴儿的结局产生影响，并与母乳喂养的婴儿进行比较。
对 2014 年 7 月至 2016 年 11 月期间患有新生儿戒断综合征（NAS）且胎龄≥35 周的新生儿进行了回顾性队列研究。主要结局包括药物治疗时间（LOT）和住院时间（LOS），以及比较标准配方和低乳糖配方的主要喂养婴儿的体重变化率，次要结局包括比较母乳喂养的主要喂养婴儿。
在调查了 249 名 NAS 婴儿的喂养方法后，对配方组进行直接比较，发现 LOS（3 天，95%置信区间[CI]：-1.1 至 7 天）、LOT（3.9 天，95%CI：-0.4 至 8.1 天）或体重变化率（-2.4 克/天，95%CI：-11.7 至 6.9 克/天）无差异。母乳喂养使 LOT 分别改善了 6.9（95%CI：3.4-10.5）和 10.8 天（95%CI：5.9-15.6），LOS 分别改善了 7.4（95%CI：4.1-10.7）和 10.3 天（95%CI：5.8-14.9），均有统计学意义，与标准配方和低乳糖配方组相比。与配方喂养组相比，母乳喂养组的婴儿体重变化率更大。
我们没有发现低乳糖配方对 NAS 婴儿有任何益处。母乳喂养与 LOS 和 LOT 的临床减少有关，但与体重下降增加有关。
· 患有新生儿戒断综合征（NAS）的婴儿最佳配方选择尚不清楚。· 许多 NAS 母亲无法进行母乳喂养。· 低乳糖配方对 NAS 结局没有影响。
