Sencan Savas, Edipoglu Ipek Saadet, Celenlioglu Alp Eren, Yolcu Gunay, Gunduz Osman Hakan
Division of Pain Medicine, Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Marmara University, Istanbul, Turkey.
Division of Pain Medicine, Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Korean J Pain. 2020 Jul 1;33(3):226-233. doi: 10.3344/kjp.2020.33.3.226.
We aimed to compare interlaminar epidural steroid injections (ILESI) and bilateral transforaminal epidural steroid injections (TFESI) on pain intensity, functional status, depression, walking distance, and the neuropathic component in patients with lumbar central spinal stenosis (LCSS).
The patients were divided into either the ILESI or the bilateral TFESI groups. Prime outcome measures include the numerical rating scale (NRS), Oswestry disability index (ODI), Beck depression inventory (BDI), and pain-free walking distance. The douleur neuropathique en 4 questions score was used as a secondary outcome measure.
A total of 72 patients were finally included. NRS, ODI, and BDI scores showed a significant decline in both groups in all follow-ups. Third-month NRS scores were significantly lower in the ILESI group ( = 0.047). The percentages of decrease in the ODI and BDI scores between the baseline and the third week and third month were significantly higher in the ILESI group ( = 0.017, = 0.001 and = 0.048, = 0.030, respectively). Pain-free walking distance percentages from the baseline to the third week and third month were significantly higher in the ILESI group ( = 0.036, < 0.001). The proportion of patients with neuropathic pain in the bilateral TFESI group significantly decreased in the third week compared to the baseline ( = 0.020).
Both ILESI and TFESI are reliable treatment options for LCSS. ILESI might be preferred because of easier application and more effectiveness. However, TFESI might be a better option in patients with more prominent neuropathic pain.
我们旨在比较椎板间硬膜外类固醇注射(ILESI)和双侧经椎间孔硬膜外类固醇注射(TFESI)对腰椎中央管狭窄症(LCSS)患者疼痛强度、功能状态、抑郁、步行距离和神经病理性成分的影响。
将患者分为ILESI组或双侧TFESI组。主要结局指标包括数字评定量表(NRS)、Oswestry功能障碍指数(ODI)、贝克抑郁量表(BDI)和无痛步行距离。四问题神经病理性疼痛评分用作次要结局指标。
最终共纳入72例患者。在所有随访中,两组的NRS、ODI和BDI评分均显著下降。ILESI组在第三个月时NRS评分显著更低(P = 0.047)。ILESI组在基线至第三周和第三个月期间ODI和BDI评分的下降百分比显著更高(分别为P = 0.017,P = 0.001和P = 0.048,P = 0.030)。ILESI组从基线到第三周和第三个月的无痛步行距离百分比显著更高(P = 0.036,P < 0.001)。与基线相比,双侧TFESI组在第三周时神经病理性疼痛患者的比例显著下降(P = 0.020)。
ILESI和TFESI都是LCSS可靠的治疗选择。由于应用更简便且更有效,ILESI可能更受青睐。然而,对于神经病理性疼痛更突出的患者,TFESI可能是更好的选择。