Sabatini M, Boyce B, Aufdemorte T, Bonewald L, Mundy G R
Department of Medicine, University of Texas Health Science Center, San Antonio 78284-7877.
Proc Natl Acad Sci U S A. 1988 Jul;85(14):5235-9. doi: 10.1073/pnas.85.14.5235.
The immune cell products interleukins 1 alpha and -beta, which stimulate osteoclast activity in vitro, are among the most potent bone resorbing factors so far described. Although it appears likely that these cytokines are involved in regulation of trabecular bone turnover, nothing is known of their effects on extracellular fluid calcium concentration. In this report, we show the effects of 72-hr subcutaneous infusions of interleukins 1 alpha and -beta on plasma calcium and bone morphology in mice. Both interleukins 1 caused a marked dose-dependent increase in the plasma calcium. In higher doses, which cause the animals to die, the plasma calcium fell preterminally. Quantitative histomorphometry of bone sections showed evidence of increased numbers of osteoclasts and bone resorption surfaces. The effects were similar to those obtained with infusions of parathyroid hormone. These data suggest that in addition to its potential influence on trabecular bone volume, interleukin 1 may also modulate extracellular fluid calcium homeostasis under conditions in which it is produced excessively.
免疫细胞产物白细胞介素1α和 -β在体外可刺激破骨细胞活性，是目前所描述的最有效的骨吸收因子之一。尽管这些细胞因子似乎参与了小梁骨转换的调节，但其对细胞外液钙浓度的影响却一无所知。在本报告中，我们展示了对小鼠皮下注射白细胞介素1α和 -β 72小时对血浆钙和骨形态的影响。两种白细胞介素1均导致血浆钙显著的剂量依赖性增加。在导致动物死亡的较高剂量下，血浆钙在死前下降。骨切片的定量组织形态计量学显示破骨细胞数量和骨吸收表面增加。这些效应与注射甲状旁腺激素所获得的效应相似。这些数据表明，白细胞介素1除了可能影响小梁骨体积外，在其过度产生的情况下，还可能调节细胞外液钙稳态。
