Li Jie, Gao Yan, Yue Wentao
Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, People's Republic of China.
Cancer Manag Res. 2020 Jun 8;12:4253-4260. doi: 10.2147/CMAR.S254596. eCollection 2020.
The Wnt signaling pathway extensively participates in diverse processes such as embryonic development, maintenance of homeostasis and tumor pathogenesis. Dickkopf-1 (DKK1), a Wnt inhibitor, plays a vital role for over the past decades regarding its role in the regulation of several types of cancers. However, studies have shown that DKK1 is expressed differently in cancer and plays a role as a cancer-promoting factor or a tumor suppressor, which is worthy of further exploration. We herein study whether DKK1 is highly expressed in all cancers and plays a crucial role in promoting cancer. Furthermore, we discussed as to which stages of cancer development it plays in. Finally, the present detection methods were introduced and indicated the clinical application of DKK1 in tumor development.
Wnt信号通路广泛参与胚胎发育、内环境稳态维持和肿瘤发病机制等多种过程。Dickkopf-1（DKK1）作为一种Wnt抑制剂，在过去几十年中，其在多种癌症类型的调控中发挥了至关重要的作用。然而，研究表明，DKK1在癌症中的表达存在差异，其既可以作为促癌因子，也可以作为肿瘤抑制因子发挥作用，这值得进一步探究。我们在此研究DKK1是否在所有癌症中均高表达，并在促进癌症发生中发挥关键作用。此外，我们还讨论了其在癌症发展的哪些阶段发挥作用。最后，介绍了目前的检测方法，并指出了DKK1在肿瘤发展中的临床应用。
