CD56表达与胰腺神经内分泌肿瘤的生物学行为相关。
CD56 Expression Is Associated with Biological Behavior of Pancreatic Neuroendocrine Neoplasms.
作者信息
Chen Xin, Guo Chuangen, Cui Wenjing, Sun Ke, Wang Zhongqiu, Chen Xiao
机构信息
Department of Radiology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 2100029, People's Republic of China.
Department of Radiology, The First Affiliated Hospital, College of Medicine Zhejiang University, Hangzhou 310003, People's Republic of China.
出版信息
Cancer Manag Res. 2020 Jun 17;12:4625-4631. doi: 10.2147/CMAR.S250071. eCollection 2020.
PURPOSE
CD56 is a neural cell adhesion molecule that plays a role in the cohesiveness of neuroendocrine cells. The aim of this study was to explore the biological values of CD56 expression in pancreatic neuroendocrine neoplasms (PNENs) and its role in predicting PNENs grades.
PATIENTS AND METHODS
A total of 138 patients with histological-proven PNENs was included (66 G1, 46 G2 and 26 G3). The clinicopathological characteristics, including mitosis count, ki67 index, chromogranin A (CgA), synaptophysin (Syn) and CD56 expression, were evaluated. We assessed the diagnostic performance of markers in predicting PNEN G3 and the association between CD56 expression and risk of G3 or organs invasion.
RESULTS
Lack of CD56 immunoreaction (CD56-) was more common in PNEN G3 than G1/G2 (31% vs 0-2%, p < 0.01). The sizes of CD56- tumors were larger than CD56 positive tumors in PNEN G3 (p < 0.01). The odds ratio (OR) of CD56- expression was 13.6 [95% confidence interval (CI): 2.1-88.1] in predicting PNEN G3. The OR of CD56- expression was 6.5 (95% CI: 1.1-38.6) and 31.9 (95% CI: 1.09-938.3) in predicting organs invasion and neuroendocrine carcinoma in PNEN G3, respectively. Tumor size (area under the curve [AUC] = 0.77 and size+CD56- expression [AUC = 0.84]) had acceptable performance in predicating PNEN G3.
CONCLUSION
Lack of CD56 immunoreaction may be a predictor and biological behavior marker for PNEN G3.
目的
CD56是一种神经细胞黏附分子，在神经内分泌细胞的黏附性中发挥作用。本研究旨在探讨CD56表达在胰腺神经内分泌肿瘤（PNENs）中的生物学价值及其在预测PNENs分级中的作用。
患者与方法
纳入138例经组织学证实的PNENs患者（66例G1级、46例G2级和26例G3级）。评估其临床病理特征，包括有丝分裂计数、ki67指数、嗜铬粒蛋白A（CgA）、突触素（Syn）和CD56表达。我们评估了这些标志物在预测PNEN G3中的诊断性能以及CD56表达与G3风险或器官侵犯之间的关联。
结果
PNEN G3中CD56免疫反应缺失（CD56-）比G1/G2更常见（31%对0-2%，p<0.01）。PNEN G3中CD56-肿瘤的大小大于CD56阳性肿瘤（p<0.01）。CD56-表达预测PNEN G3的比值比（OR）为13.6[95%置信区间（CI）：2.1-88.1]。CD56-表达预测PNEN G3中器官侵犯和神经内分泌癌的OR分别为6.5（95%CI：1.1-38.6）和31.9（95%CI：1.09-938.3）。肿瘤大小（曲线下面积[AUC]=0.77）以及大小+CD56-表达（AUC=0.84）在预测PNEN G3方面具有可接受的性能。
结论
CD56免疫反应缺失可能是PNEN G3的一个预测指标和生物学行为标志物。
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