Clyde D F, McCarthy V C
Am J Trop Med Hyg. 1977 May;26(3):562-3. doi: 10.4269/ajtmh.1977.26.562.
Glucose-6-phosphate dehydrogenase-normal adult volunteers infected with mosquito-bone Chesson strain vivax malaria were treated with chloroquine and primaquine during the initial attack. Administration of 60 mg (base) of primaquine daily for 7 days was as effective in preventing relapse as is the regimen customarily used for the radical cure of infections produced by this strain, namely, 30 mg daily for 14 days. However, it is stressed that because of the risk of primaquine-induced hemolysis in individuals having genetically-transmitted erythrocyte abnormalities this high dosage should not be used routinely.
用感染了按蚊传播的切森株间日疟的葡萄糖-6-磷酸脱氢酶正常的成年志愿者在初次发作时用氯喹和伯氨喹进行治疗。每天给予60毫克（碱基）伯氨喹，共7天，在预防复发方面与通常用于根治该菌株所致感染的方案（即每天30毫克，共14天）一样有效。然而，需要强调的是，由于有遗传传递的红细胞异常的个体存在伯氨喹诱发溶血的风险，这种高剂量不应常规使用。
