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新诊断痰涂片阳性肺结核老年患者与青年患者临床、影像学和实验室参数比较:一项基于医院的横断面研究

Comparison of Clinical, Radiological and Laboratory Parameters Between Elderly and Young Patient With Newly Diagnosed Smear Positive Pulmonary Tuberculosis: A Hospital-Based Cross Sectional Study.

作者信息

Rajaram Manju, Malik Archana, Mohanty Mohapatra Madhusmita, Vijayageetha Mathavaswami, Mahesh Babu Vemuri, Vally Soundara, Saka Vinod Kumar

机构信息

Pulmonary Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND.

Internal Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND.

出版信息

Cureus. 2020 May 27;12(5):e8319. doi: 10.7759/cureus.8319.

Abstract

Introduction To compare clinical, radiological and haematological manifestations among newly diagnosed smear positive tuberculosis patients between Group I (Elderly >60 yrs) and Group II (Younger age between 13 and 60 years). Methodology This was a hospital-based cross-sectional study conducted at the out-patient department of pulmonary medicine, between March 2014 and December 2017. There were 61 patients in Group I (Elderly > 60 yrs) and 110 patients in Group II (Younger age between 13 and 60 years). Continuous variables were compared using student's t-test and Mann-Whitney test. Chi square test and Fischer test was used for analysing categorical variables. All statistics were two-tailed, and a p-value of 0.05 was considered to be statistically significant. Results The mean age for Group I (Elderly >60 yrs) was 65 ± 2 years and for the Group II (Younger age between 13 and 60 years) was 40 ± 1 years. There was a statistically significant association of cavitation with infiltrates (p = 0.007) in younger age group. Bilateral multiple zone (48, 64.86%) involvements were commonly observed in both the age groups. There was no significant difference between two groups with regard to haematological and clinical parameters. Conclusion We did not find any difference in the presentation of tuberculosis in both the groups. Radiologically, there was more of cavitating lesion in younger age group. So, they should be isolated and followed up at regular intervals.

摘要

引言

比较第一组(年龄>60岁的老年人)和第二组(年龄在13至60岁之间的年轻人)新诊断的涂片阳性肺结核患者的临床、放射学和血液学表现。

方法

这是一项于2014年3月至2017年12月在肺科门诊进行的基于医院的横断面研究。第一组(年龄>60岁的老年人)有61例患者,第二组(年龄在13至60岁之间的年轻人)有110例患者。连续变量采用学生t检验和曼-惠特尼检验进行比较。卡方检验和费舍尔检验用于分析分类变量。所有统计均为双侧检验,p值<0.05被认为具有统计学意义。

结果

第一组(年龄>60岁的老年人)的平均年龄为65±2岁,第二组(年龄在13至60岁之间的年轻人)的平均年龄为40±1岁。在较年轻年龄组中,空洞与浸润之间存在统计学显著关联(p = 0.007)。两个年龄组均常见双侧多区域受累(48例,64.86%)。两组在血液学和临床参数方面无显著差异。

结论

我们未发现两组肺结核表现有任何差异。放射学上,较年轻年龄组空洞性病变更多。因此,应对他们进行隔离并定期随访。

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