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表现为胰腺炎的肝样腺癌

Hepatoid Adenocarcinoma Presenting as Pancreatitis.

作者信息

Chaudhari Rahul, Murphy Katherine, Schwartz Stephen, Chaudhari Jigisha, Ho Immanuel, Nunes Frederick

机构信息

Department of Medicine, Pennsylvania Hospital of the University of Pennsylvania Health System, Philadelphia, PA.

Department of Pathology, Pennsylvania Hospital of the University of Pennsylvania Health System, Philadelphia, PA.

出版信息

ACG Case Rep J. 2020 May 7;7(5):e00381. doi: 10.14309/crj.0000000000000381. eCollection 2020 May.

DOI:10.14309/crj.0000000000000381
PMID:32607381
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7289282/
Abstract

Hepatoid adenocarcinoma (HAC) is an uncommon and aggressive type of adenocarcinoma, typically affecting the middle-aged and elderly. The morphological features of the HAC resemble hepatocellular carcinoma. Presenting symptoms may include upper abdominal pain, hematemesis, back pain, and palpable abdominal mass. HAC has no proven therapy, and the prognosis is extremely poor. Early surgical removal with chemotherapy remains the standard of care. We describe one of the youngest patients in the literature with HAC who presented with acute pancreatitis. The diagnostic workup was confused by diffuse lymphadenopathy and elevated β-human chorionic gonadotropin making lymphoma and germ cell tumor likely possibilities until immunohistochemistry confirmed the diagnosis.

摘要

肝样腺癌（HAC）是一种罕见且侵袭性强的腺癌类型，通常影响中老年人。HAC的形态学特征类似于肝细胞癌。临床表现可能包括上腹部疼痛、呕血、背痛和可触及的腹部肿块。HAC尚无经证实有效的治疗方法，预后极差。早期手术切除并辅以化疗仍是标准的治疗方案。我们报道了文献中最年轻的HAC患者之一，该患者表现为急性胰腺炎。弥漫性淋巴结病和β-人绒毛膜促性腺激素升高使诊断检查结果混淆，在免疫组化确诊之前，淋巴瘤和生殖细胞肿瘤是可能的诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa42/7289282/dfd09979d2d4/ac9-7-e00381-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa42/7289282/343f6d684b52/ac9-7-e00381-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa42/7289282/275f9a565539/ac9-7-e00381-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa42/7289282/299ead4bc97b/ac9-7-e00381-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa42/7289282/dfd09979d2d4/ac9-7-e00381-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa42/7289282/343f6d684b52/ac9-7-e00381-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa42/7289282/275f9a565539/ac9-7-e00381-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa42/7289282/299ead4bc97b/ac9-7-e00381-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa42/7289282/dfd09979d2d4/ac9-7-e00381-g004.jpg

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Therapeutic Approaches to Gastric Hepatoid Adenocarcinoma: Current Perspectives.胃肝样腺癌的治疗方法：当前观点
Ther Clin Risk Manag. 2019 Dec 23;15:1469-1477. doi: 10.2147/TCRM.S204303. eCollection 2019.
2
Gastric adenocarcinoma with enteroblastic differentiation should be differentiated from hepatoid adenocarcinoma: A study with emphasis on clear cells and clinicopathologic spectrum.胃腺泡细胞癌应与肝样腺癌相鉴别：一项以透明细胞为重点的临床病理谱研究。
Pathol Res Pract. 2019 Sep;215(9):152525. doi: 10.1016/j.prp.2019.152525. Epub 2019 Jun 28.
3
Hepatoid adenocarcinoma of the stomach: a unique subgroup with distinct clinicopathological and molecular features.
胃肝样腺癌：具有独特临床病理和分子特征的独特亚群。
Gastric Cancer. 2019 Nov;22(6):1183-1192. doi: 10.1007/s10120-019-00965-5. Epub 2019 Apr 15.
4
Clinicopathological Characteristics and Prognosis of Hepatoid Adenocarcinoma of the Stomach: Evaluation of a Pooled Case Series.胃肝样腺癌的临床病理特征和预后：汇总病例系列评估。
Curr Med Sci. 2018 Dec;38(6):1054-1061. doi: 10.1007/s11596-018-1983-1. Epub 2018 Dec 7.
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Chemotherapy of metastatic hepatoid adenocarcinoma: Literature review and two case reports with cisplatin etoposide.转移性肝样腺癌的化疗：文献综述及两例顺铂联合依托泊苷治疗的病例报告
Oncol Lett. 2018 Jan;15(1):48-54. doi: 10.3892/ol.2017.7263. Epub 2017 Oct 25.
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Front Med (Lausanne). 2017 Sep 28;4:164. doi: 10.3389/fmed.2017.00164. eCollection 2017.
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Gastric hepatoid adenocarcinoma resulting in a spontaneous gastric perforation: a case report and review of the literature.导致自发性胃穿孔的胃肝样腺癌：一例报告并文献复习
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