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应用于淋巴结穿刺液的Xpert Ultra检测出现假利福平耐药：一例报告

False Rifampicin Resistance in Xpert Ultra Applied to Lymph Node Aspirate: A Case Report.

作者信息

Ng Kamela C S, Rigouts Leen, de Jong Bouke C, Lynen Lutgarde

机构信息

Mycobacteriology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, United States.

出版信息

Open Forum Infect Dis. 2020 Jun 2;7(6):ofaa204. doi: 10.1093/ofid/ofaa204. eCollection 2020 Jun.

DOI:10.1093/ofid/ofaa204
PMID:32607388
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7307434/
Abstract

A 36-year-old male patient was diagnosed with tuberculosis in Antwerp, Belgium, in May 2018. His lymph node aspirate initially tested rifampicin resistant in Xpert MTB/RIF Ultra, but tested susceptible in all other tests including targeted deep sequencing due to a rare matrix effect in the Xpert MTB/RIF Ultra reaction tube.

摘要

一名36岁男性患者于2018年5月在比利时安特卫普被诊断为结核病。他的淋巴结穿刺液最初在Xpert MTB/RIF Ultra检测中对利福平耐药，但在所有其他检测（包括靶向深度测序）中均检测为敏感，这是由于Xpert MTB/RIF Ultra反应管中存在罕见的基质效应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1095/7307434/07ab5ab80543/ofaa204f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1095/7307434/07ab5ab80543/ofaa204f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1095/7307434/07ab5ab80543/ofaa204f0001.jpg

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本文引用的文献

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J Clin Microbiol. 2019 Oct 23;57(11). doi: 10.1128/JCM.00717-19. Print 2019 Nov.
2
Assessment of the Xpert MTB/RIF Ultra assay on rapid diagnosis of extrapulmonary tuberculosis.评估 Xpert MTB/RIF Ultra assay 在快速诊断肺外结核中的应用。
Int J Infect Dis. 2019 Apr;81:91-96. doi: 10.1016/j.ijid.2019.01.050. Epub 2019 Feb 7.
3
Evaluation of the Xpert MTB/RIF Ultra Assay for Direct Detection of Mycobacterium tuberculosis Complex in Smear-Negative Extrapulmonary Samples.
评估 Xpert MTB/RIF Ultra assay 直接检测涂片阴性肺外样本中的结核分枝杆菌复合群。
J Clin Microbiol. 2018 Aug 27;56(9). doi: 10.1128/JCM.00659-18. Print 2018 Sep.
4
Xpert Ultra Can Unambiguously Identify Specific Rifampin Resistance-Conferring Mutations.Xpert Ultra 能够明确鉴定出特定的利福平耐药性相关突变。
J Clin Microbiol. 2018 Aug 27;56(9). doi: 10.1128/JCM.00686-18. Print 2018 Sep.
5
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