School of Science, Zhejiang A & F University, Hangzhou, 311300, Zhejiang, China.
School of Animal Science and Technology, Zhejiang A & F University, Hangzhou, 311300, Zhejiang, China.
Environ Geochem Health. 2020 Nov;42(11):3851-3864. doi: 10.1007/s10653-020-00630-2. Epub 2020 Jun 30.
Baicalin (BC)-rare earth metal complexes [BMCs (BC-Ce, BC-La, and BC-Y)] were synthesized by a complexation coordination method. A mouse tumor model with SMMC-7721 cells was used to examine BMCs for their anti-tumor activities in vivo. The results show that the three new BMCs, NaCe (CHO)·10HO, NaLa (CHO)·8HO, and NaY (CHO)·6HO significantly inhibited SMMC-7721 cell proliferation, since the BMCs may induce the tumor apoptosis in a dose-dependent manner through decreasing cell membrane fluidity and mitochondrial membrane potential depolarization, blocking of the cell cycle at the G/M phase, and increasing the expression of Bax and reducing the expression of Bcl-2. The effectiveness order of these three BCMs was as follows: BC-Ce > BC-La > BC-Y > BC. It is concluded that BC-Ce, BC-La, and BC-Y possess potent anti-tumor effects and may be a novel group of anti-tumor drugs. The novel baicalin-rare earth metal complexes (BMC) were synthesized, the anti-tumor effects of the BMC on SMMC-7721 cell analyzed comprehensively.
黄芩苷（BC）-稀土金属配合物[BMCs（BC-Ce、BC-La 和 BC-Y）]通过配位络合方法合成。使用 SMMC-7721 细胞的小鼠肿瘤模型来体内研究 BMCs 的抗肿瘤活性。结果表明，三种新型 BMCs，NaCe（CHO）·10H2O、NaLa（CHO）·8H2O 和 NaY（CHO）·6H2O 显著抑制 SMMC-7721 细胞增殖，因为 BMCs 可能通过降低细胞膜流动性和线粒体膜电位去极化、阻断细胞周期在 G/M 期以及增加 Bax 的表达和降低 Bcl-2 的表达来诱导肿瘤细胞凋亡。这三种 BMC 的效果顺序如下：BC-Ce>BC-La>BC-Y>BC。结论：BC-Ce、BC-La 和 BC-Y 具有很强的抗肿瘤作用，可能是一类新型抗肿瘤药物。合成了新型黄芩苷-稀土金属配合物（BMC），全面分析了 BMC 对 SMMC-7721 细胞的抗肿瘤作用。
