Department of Histopathology, 5294The Christie NHS Foundation Trust, Manchester, UK.
Department of Haematology, The Christie NHS Foundation Trust, Manchester, UK.
Int J Surg Pathol. 2021 May;29(3):289-293. doi: 10.1177/1066896920938130. Epub 2020 Jul 1.
E-cadherin is expressed in hematopoietic erythroid precursors, but to our knowledge, its expression in blastic plasmacytoid dendritic cell neoplasm (BPDCN) has not been described. We report a case of BPDCN showing strong expression of E-cadherin, arising in a patient with history of primary myelofibrosis. Four more cases of BPDCN tested all showed strong expression of E-cadherin. Lack of awareness of this pattern of expression may lead to erroneous diagnosis of acute erythroid leukemia. It is increasingly becoming important to correctly identify this group of neoplasms, as approved new anti-CD123-targeted therapies are becoming available.
E-钙黏蛋白在造血红细胞前体中表达，但据我们所知，其在原始骨髓纤维化患者中发生的母细胞性浆细胞样树突细胞肿瘤（BPDCN）中的表达尚未被描述。我们报告了一例 BPDCN 病例，该病例显示 E-钙黏蛋白强表达，发生于原发性骨髓纤维化病史的患者中。另外 4 例 BPDCN 病例的检测均显示 E-钙黏蛋白强表达。如果不了解这种表达模式，可能会导致误诊为急性红细胞性白血病。随着越来越多的新型抗 CD123 靶向治疗药物获得批准，正确识别这组肿瘤变得越来越重要。
