环孢菌素A对近交系大鼠同种抗体反应的影响：具有抗独特型活性血清因子的初步证据。
The influence of cyclosporin A on alloantibody responses in inbred rats: provisional evidence for a serum factor with antiidiotypic activity.
作者信息
Cunningham C, Power D A, Stewart K N, Catto G R
机构信息
Department of Medicine, Aberdeen Royal Infirmary, Foresterhill, UK.
出版信息
Clin Exp Immunol. 1988 Apr;72(1):130-5.
The effect of cyclosporin A (CsA) on alloantibody synthesis has been investigated in inbred F344 (RTl1v1) rats receiving weekly transfusions of DA (RT1a) rat whole blood. Whereas repeated transfusion resulted in a persistent alloantibody response (Group I) administration of CsA (15 mg/kg/day) from either days 0-7 (Group II), days 8-49 (Group III) or days 15-49 (Group IV) resulted in the eventual suppression of alloantibody responses before the end of the experiment on day 49. Antiidiotypic activity was detected in sera obtained on day 49 from animals in Groups II, III and IV, shown to reside in the serum fraction of apparent molecular mass of between 150 and 170 kD and to be specific for alloantisera raised in F344 and the closely related LEW (RTl1) rats but not the unrelated AO (RTlu) strain. These experiments suggest that the immunosuppressive action of CsA may, in part, be due to the development of anti-idiotypic activity whose nature remains to be more fully characterized.
研究了环孢素A（CsA）对接受每周一次DA（RT1a）大鼠全血输注的近交系F344（RTl1v1）大鼠同种抗体合成的影响。重复输血导致持续的同种抗体反应（I组），而从第0 - 7天（II组）、第8 - 49天（III组）或第15 - 49天（IV组）给予CsA（15 mg/kg/天），在第49天实验结束前最终抑制了同种抗体反应。在第49天从II组、III组和IV组动物获得的血清中检测到抗独特型活性，显示其存在于表观分子量在150至170 kD之间的血清组分中，并且对在F344和密切相关的LEW（RTl1）大鼠中产生的同种抗血清具有特异性，但对不相关的AO（RTlu）品系无特异性。这些实验表明，CsA的免疫抑制作用可能部分归因于抗独特型活性的产生，其性质仍有待更全面地表征。
Zotero 插件