Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.
Chem Commun (Camb). 2020 Aug 7;56(61):8663-8666. doi: 10.1039/d0cc02486d. Epub 2020 Jul 1.
Amphiphilic polyphenylene dendrimers (PPDs) with distinct lipophilic and positively or negatively charged surface groups were adsorbed onto liposomes and their impact on protein adsorption in blood plasma was studied. The PPD corona reduced binding of specific opsonins and increased the adsorption of proteins controlling cellular uptake based on their surface patches.
具有独特亲脂性和亲/负表面基团的两亲性多苯基树枝状聚合物（PPD）被吸附到脂质体上，并研究了它们对血浆中蛋白质吸附的影响。PPD 冠减少了特定调理素的结合，并增加了基于其表面斑块控制细胞摄取的蛋白质的吸附。
