Beerthuizen G I, Goris R J, Bredee J J, Mashhour Y A, Kimmich H P, van der Kley A J, Kreuzer F
Department of Surgery, University Hospital Nijmegen, The Netherlands.
Crit Care Med. 1988 Aug;16(8):748-50. doi: 10.1097/00003246-198808000-00003.
In eight patients who underwent elective coronary bypass operation, skeletal muscle PO2 was measured with a polarographic needle electrode as an index of peripheral tissue perfusion to study recovery after extracorporeal circulation. Measurements of skeletal muscle PO2 and O2 supply to the tissues were obtained immediately after ICU admission and after 2, 4, 8, and 16 h. During the first 2 h, mean arterial BP was high, mixed venous PO2 decreased, the arteriovenous O2 difference increased, and skeletal muscle PO2 decreased. The P50 of the O2 dissociation curve on ICU admission was decreased and thereafter increased to a maximal value at 8 h, and normalized again after 16 h. After the initial decrease, the median of the skeletal muscle PO2 returned to normal values, but decreased again after 16 h. The results showed that, during the first 4 h postoperatively, microcirculatory changes occurred despite normal cardiovascular and respiratory variables.
在8例接受择期冠状动脉搭桥手术的患者中，使用极谱针电极测量骨骼肌PO2作为外周组织灌注指标，以研究体外循环后的恢复情况。在入住重症监护病房（ICU）后即刻以及2、4、8和16小时后，测量骨骼肌PO2和组织的氧气供应。在最初的2小时内，平均动脉血压较高，混合静脉PO2降低，动静脉氧差增加，骨骼肌PO2降低。入住ICU时氧解离曲线的P50降低，此后在8小时时升高至最大值，并在16小时后再次恢复正常。在最初降低后，骨骼肌PO2的中位数恢复到正常值，但在16小时后再次降低。结果表明，术后最初4小时内，尽管心血管和呼吸变量正常，但仍发生了微循环变化。
