具有光漂白稳定性和可调光敏性能的温敏共轭聚合物的研制。

Development of A Thermo-Responsive Conjugated Polymer with Photobleaching-Resistance Property and Tunable Photosensitizing Performance.

机构信息

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.

School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.

出版信息

Macromol Rapid Commun. 2020 Aug;41(15):e2000249. doi: 10.1002/marc.202000249. Epub 2020 Jul 1.

DOI:10.1002/marc.202000249

PMID:32608545

Abstract

A thermo-responsive conjugated polymer, PFBT-gPA is synthesized by grafting the poly(N-isopropylacrylamide) (PNIPAAm) to the side chains of a conjugated polyfluorene derivative through atom transfer radical polymerization (ATRP). PFBT-gPA undergoes a reversible phase transition in water below and above the lower critical solution temperature (LCST) and the process is studied by differential scanning calorimetry (DSC) analysis and UV/vis absorption spectra. PFBT-gPA shows a good photostability under UV light irradiation especially above the LCST. Moreover, the photosensitizing performance of PFBT-gPA could be tuned simply by changing temperature. The unique properties of PFBT-gPA promise its potential applications in sensing and photodynamic therapy.

摘要

通过原子转移自由基聚合（ATRP），将聚（N-异丙基丙烯酰胺）（PNIPAAm）接枝到共轭聚芴衍生物的侧链上，合成了一种温敏共轭聚合物 PFBT-gPA。PFBT-gPA 在低于和高于低临界溶液温度（LCST）下的水中发生可逆相转变，通过差示扫描量热法（DSC）分析和紫外/可见吸收光谱研究了这一过程。PFBT-gPA 在紫外光照射下表现出良好的光稳定性，特别是在 LCST 以上。此外，PFBT-gPA 的光致敏感性可以通过简单地改变温度来调节。PFBT-gPA 的独特性质使其有望在传感和光动力治疗方面得到应用。