散发性迟发性皮肤卟啉症患者中HLA - A3频率增加。
Increased frequency of HLA-A3 in subjects with sporadic porphyria cutanea tarda.
作者信息
Edwards C Q, Griffen L M, Kushner J P
机构信息
Department of Medicine, University of Utah College of Medicine, Salt Lake City.
出版信息
Tissue Antigens. 1988 May;31(5):250-3. doi: 10.1111/j.1399-0039.1988.tb02091.x.
The HLA-A3 alloantigen, usually associated with the hemochromatosis gene, was detected in 12 of 18 patients (67%) with sporadic porphyria cutanea tarda but in only 23 per cent of 328 normal subjects (p = 0.0006). This difference remained significant after correcting for the number of HLA-A locus antigens tested (p = 0.025). These results suggest that an HLA-linked hemochromatosis allele is present and may account for the iron abnormalities in many patients with sporadic porphyria cutanea tarda.
HLA - A3同种抗原通常与血色素沉着症基因相关，在18例迟发性皮肤卟啉病散发病例中有12例（67%）检测到该抗原，而在328名正常受试者中仅23%检测到（p = 0.0006）。在校正所检测的HLA - A位点抗原数量后，这种差异仍然显著（p = 0.025）。这些结果表明，存在一种与HLA相关的血色素沉着症等位基因，它可能是许多迟发性皮肤卟啉病散发病例中铁代谢异常的原因。
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