Le Moal M A, Truffa-Bachi P
Département d'Immunologie, Institut Pasteur, Paris, France.
Cell Immunol. 1988 Aug;115(1):24-35. doi: 10.1016/0008-8749(88)90159-1.
Urtica dioica agglutinin, a small-molecular-weight lectin purified from stinging nettle rhizomes, induces murine cell proliferation. U. dioica agglutinin is a specific T-cell mitogen for both thymocytes and spleen T lymphocytes; its mitogenic properties are strictly dependent on the presence of accessory cells. The kinetics of proliferation are markedly different from those of the classical T-cell mitogen concanavalin A, with a 2 to 3-day delay for both splenic and thymic populations and a rate of DNA synthesis twofold lower than that observed with concanavalin A. The late T-lymphocyte proliferation induced by U. dioica agglutinin correlates well with (i) the observed late interleukin-2 production and interleukin-2 receptor expression, and (ii) the long-lasting cyclosporin A-sensitive early activation period. In contrast, the production of interleukin-1 is not different, both in terms of concentration and kinetics, from that observed with concanavalin A.
荨麻凝集素是一种从小荨麻根茎中纯化得到的小分子凝集素，可诱导小鼠细胞增殖。荨麻凝集素是胸腺细胞和脾脏T淋巴细胞的特异性T细胞有丝分裂原；其促有丝分裂特性严格依赖于辅助细胞的存在。增殖动力学与经典T细胞有丝分裂原伴刀豆球蛋白A明显不同，脾脏和胸腺细胞群体均有2至3天的延迟，DNA合成速率比伴刀豆球蛋白A观察到的低两倍。荨麻凝集素诱导的晚期T淋巴细胞增殖与（i）观察到的晚期白细胞介素-2产生和白细胞介素-2受体表达，以及（ii）持久的环孢菌素A敏感早期激活期密切相关。相比之下，白细胞介素-1的产生在浓度和动力学方面与伴刀豆球蛋白A观察到的没有差异。
