Verma V, Schmidt H, Richter H P
I. Physiologisches Institut der Universität des Saarlandes, Homburg/Saar, Federal Republic of Germany.
J Ultrastruct Mol Struct Res. 1988 Apr;99(1):27-37. doi: 10.1016/0889-1605(88)90030-4.
Mixed fiber bundles as well as separated slow and fast fibers from normal and denervated muscles of Rana temporaria were freeze-fractured. The membranes of both fiber types are distinguished in this species by the presence of fairly regularly distributed particle aggregates or arrays of different shapes and sizes; the number per unit area of the membrane is six times higher in fast than in slow fibers. The intramembrane particle (IMP) density is higher in slow than in fast fibers. After denervation, the fast fiber membrane structure does not change whereas the slow fiber membrane acquires the characteristics of the fast fiber, i.e., an increase in the density of particle arrays and a decrease in IMP density. These changes in the slow fiber membrane are compared to the altered physiological properties of this fiber type after denervation.
对来自林蛙正常和去神经肌肉的混合纤维束以及分离出的慢肌纤维和快肌纤维进行了冷冻蚀刻。在该物种中，两种纤维类型的膜通过存在分布相当规则的不同形状和大小的颗粒聚集体或阵列来区分；快肌纤维膜每单位面积的颗粒数量比慢肌纤维高六倍。慢肌纤维的膜内颗粒（IMP）密度高于快肌纤维。去神经后，快肌纤维膜结构不变，而慢肌纤维膜获得了快肌纤维的特征，即颗粒阵列密度增加，IMP密度降低。将慢肌纤维膜的这些变化与去神经后该纤维类型改变的生理特性进行了比较。
