Ochałek T, Cadel Z
Department of Microbiology and Immunology, Jan Zurzycki Institute of Molecular Biology, Jagiellonian University, Kraków, Poland.
Neoplasma. 1988;35(3):271-8.
T lymphocytes isolated from a bulk culture of splenocytes exposed in vitro to polyoma TAA and IL-2, taken from CBA mice with transplanted polyoma tumors, exhibited both antitumor and DTH activity to polyoma TAA, associated with the Lyt 1+ phenotype, and also showed an increased affinity to TAA. The antitumor efficacy of adoptive immunotherapy, consisting in the i.p. administration of these TAA-driven lymphocytes, showed time and IL-2 dependence, while transferred cells were capable of eliciting DTH independently of IL-2. The suppression of tumor growth observed in 70% of the animals in the optimal variant seems to result from the cooperation of transferred lymphocytes with the recipients own lymphocytes.
从移植了多瘤病毒肿瘤的CBA小鼠脾脏细胞体外暴露于多瘤病毒肿瘤相关抗原（TAA）和白细胞介素-2（IL-2）的大量培养物中分离出的T淋巴细胞，对多瘤病毒TAA表现出抗肿瘤和迟发型超敏反应（DTH）活性，与Lyt 1+表型相关，并且对TAA的亲和力也增加。过继免疫疗法的抗肿瘤功效在于腹腔注射这些由TAA驱动的淋巴细胞，显示出时间和IL-2依赖性，而转移的细胞能够独立于IL-2引发DTH。在最佳方案中，70%的动物中观察到的肿瘤生长抑制似乎是由于转移的淋巴细胞与受体自身淋巴细胞的合作所致。
