Faculty of Health, University of Plymouth, Plymouth, Devon, UK.
Pediatr Obes. 2020 Dec;15(12):e12685. doi: 10.1111/ijpo.12685. Epub 2020 Jul 2.
To investigate associations between androgens (testosterone, dehydroepiandrosterone sulphate [DHEAS] and androstenedione), adiposity, fat distribution and insulin resistance (IR) during childhood and adolescence.
Three hundred and seven children (170 [55.4%] boys; 137 [44.6%] girls) recruited at age 5 and studied annually until age 16: androgens (liquid chromatography tandem-mass spectrometry), anthropometry, body composition (dual-energy x-ray absorptiometry) and IR (homeostasis model assessment).
Early adiposity was associated with earlier detection of androstenedione in both sexes, and DHEAS in boys. At puberty, higher androgen levels were associated with favourable metabolic changes in boys, but adverse metabolic effects in girls. In boys, higher free testosterone (FT) was associated with lower body fat and android/gynoid fat ratio (AGR) (both P < .001), but in girls higher total testosterone was associated with higher AGR. In girls only, higher androstenedione (P = .02) and FT (P = .01) was associated with higher IR during puberty.
In pre-pubertal children, adiposity is associated with higher secretion of androgen precursors. After pubertal onset, higher testosterone is associated with lower adiposity and AGR in boys, but higher AGR and IR in girls. Therefore, androgens have modest sex-specific associations with children's total body fat, fat distribution and IR.
研究儿童和青少年时期雄激素（睾酮、硫酸脱氢表雄酮[DHEAS]和雄烯二酮）、肥胖、脂肪分布和胰岛素抵抗（IR）之间的关系。
招募了 307 名儿童（170 名[55.4%]男孩；137 名[44.6%]女孩），他们在 5 岁时被招募并每年进行研究直到 16 岁：雄激素（液相色谱串联质谱法）、人体测量学、身体成分（双能 X 射线吸收法）和 IR（稳态模型评估）。
早期肥胖与两性中雄烯二酮的早期检测以及男孩 DHEAS 的早期检测有关。在青春期，较高的雄激素水平与男孩有利的代谢变化有关，但与女孩不利的代谢影响有关。在男孩中，较高的游离睾酮（FT）与较低的体脂肪和安卓/女性脂肪比（AGR）（均 P<0.001）有关，但在女孩中，较高的总睾酮与较高的 AGR 有关。仅在女孩中，较高的雄烯二酮（P=0.02）和 FT（P=0.01）与青春期时较高的 IR 有关。
在青春期前的儿童中，肥胖与雄激素前体的分泌较高有关。在青春期开始后，较高的睾酮与男孩较低的体脂肪和 AGR 有关，但与女孩较高的 AGR 和 IR 有关。因此，雄激素与儿童总体脂肪、脂肪分布和 IR 具有适度的性别特异性关联。
