Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Clinical Psychology and Psychotherapy, University of Zurich, Zurich, Switzerland.
J Child Adolesc Psychopharmacol. 2021 Feb;31(1):53-55. doi: 10.1089/cap.2020.0052. Epub 2020 Jun 30.
Although males and females gain comparable weight when prescribed second-generation antipsychotics (SGAs), males may be uniquely vulnerable to an array of endocrinological, inflammatory, and psychosocial adverse drug effects. This opinion piece reviews work in each of these three areas for consideration. Androgens may decrease both through hypothalamic-pituitary-gonadal axis dysregulation and as a consequence of increased adiposity. Testosterone has anti-inflammatory properties, and declining levels as well as many other factors may influence overall immunological functioning. Psychosocial stressors are gender specific in obesity, and SGA-induced obesity may affect males in unique and severe ways. This opinion piece supports the framework of the World Federation of Societies of Biological Psychiatry's Task Force on Men's Mental Health to advocate for further studies concerning the adverse drug effects of SGAs as unique manifested in male children, adolescents, and young men.
尽管男性和女性在服用第二代抗精神病药物（SGAs）时体重增加相当，但男性可能特别容易受到一系列内分泌、炎症和心理社会不良药物作用的影响。这篇观点文章回顾了这三个领域的相关研究工作。雄激素可能通过下丘脑-垂体-性腺轴失调和肥胖而减少。睾酮具有抗炎特性，水平下降以及许多其他因素可能会影响整体免疫功能。心理社会应激源在肥胖中具有性别特异性，而 SGA 引起的肥胖可能以独特而严重的方式影响男性。这篇观点文章支持世界生物精神病学学会联合会男性心理健康工作组的框架，倡导进一步研究 SGAs 的不良药物作用，因为这些作用在男性儿童、青少年和年轻男性中表现得更为独特。
