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减重手术与胃食管反流病的发病机制。

Bariatric Surgery and the Mechanisms of Gastroesophageal Reflux Disease.

机构信息

ELSAN, Clinique Bouchard, Marseille, France.

ELSAN, Clinique Saint Michel, Toulon, France.

出版信息

J Laparoendosc Adv Surg Tech A. 2020 Aug;30(8):907-911. doi: 10.1089/lap.2020.0323. Epub 2020 Jul 2.

DOI:10.1089/lap.2020.0323
PMID:32614705
Abstract

The association between obesity and gastroesophageal reflux disease (GERD) is very well known and the pathophysiology of GERD is not completely understood but is likely to have a multifactorial nature especially after bariatric procedures. The current editorial summarizes the principal mechanisms involved in the reflux disease following different bariatric procedures. Laparoscopic adjustable gastric banding could reduce the gastroesophageal reflux in the short term in some cases, but overeating will inevitably lead to enlargement of the pouch with loss of its antireflux properties. Although the laparoscopic Roux-en-Y gastric bypass was considered the gold standard procedure for obese patients with reflux disease, many patients had at least one complication within their follow-up period. One anastomosis gastric bypass remains a controversial procedure for GERD, especially when it is proposed as revisional surgery after laparoscopic sleeve gastrectomy. As revisional surgery, either single anastomosis duodeno-ileostomy (SADI) or duodenal switch (DS) have little or no impact on GERD and in our experience the indication for SADI/DS is a valid option in case of absence of any symptoms of reflux. The effect of sleeve for GERD is contradictory. For those with moderate reflux, since specific procedure guidelines are missing, surgical treatment for morbid obese patients must be selected according to the clinical characteristics of the patient, his eating habits and patient willingness. It should be based on a preoperative workup with shared decision making, with the double purpose of treating both GERD and obesity.

摘要

肥胖与胃食管反流病(GERD)之间的关联是众所周知的,而 GERD 的病理生理学尚未完全了解,但可能具有多因素性质,尤其是在进行减肥手术后。本社论总结了不同减肥手术后反流病涉及的主要机制。腹腔镜可调节胃束带术在某些情况下可以在短期内减少胃食管反流,但暴饮暴食会不可避免地导致袋状增大,失去其抗反流特性。虽然腹腔镜 Roux-en-Y 胃旁路术被认为是肥胖伴反流病患者的金标准手术,但许多患者在随访期间至少发生了一次并发症。单吻合口十二指肠空肠旁路术仍然是 GERD 的有争议的手术,尤其是在作为腹腔镜袖状胃切除术的翻修手术后提出时。作为翻修手术,单吻合口十二指肠空肠旁路术(SADI)或十二指肠转位术(DS)对 GERD 的影响很小或没有,根据我们的经验,SADI/DS 的适应证是在没有任何反流症状的情况下的有效选择。袖状胃切除术对 GERD 的效果是矛盾的。对于那些有中度反流的患者,由于缺乏特定的手术指南,因此必须根据患者的临床特征、饮食习惯和患者意愿来选择肥胖症患者的手术治疗。它应该基于具有共同决策的术前评估,其双重目的是治疗 GERD 和肥胖症。

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Efficacy of Nissen Sleeve Gastrectomy on Mid-term Barrett's Esophagus Regression.Nissen 袖状胃切除术对中期 Barrett 食管消退的疗效。
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