Liu Mengjie, Wade John, Hossain Mohammed Akhter
Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC 3010, Australia.
Curr Protein Pept Sci. 2020;21(10):955-964. doi: 10.2174/1389203721666200702131457.
Ghrelin is a 28-amino acid octanoylated peptide hormone that is implicated in many physiological and pathophysiological processes. Specific visualization of ghrelin and its cognate receptor using traceable ligands is crucial in elucidating the localization, functions, and expression pattern of the peptide's signaling pathway. Here 12 representative radio- and fluorescently-labeled peptide-based ligands are reviewed for in vitro and in vivo imaging studies. In particular, the focus is on their structural features, pharmacological properties, and applications in further biochemical research.
胃饥饿素是一种由28个氨基酸组成的辛酰化肽激素，参与许多生理和病理生理过程。使用可追踪配体对胃饥饿素及其同源受体进行特异性可视化，对于阐明该肽信号通路的定位、功能和表达模式至关重要。本文综述了12种具有代表性的基于肽的放射性和荧光标记配体，用于体外和体内成像研究。特别关注它们的结构特征、药理学特性以及在进一步生化研究中的应用。
