Department of Geriatric Medicine, Bezmialem Vakif University, Faculty of Medicine, Istanbul, Turkey.
Department of Geriatric Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
Age Ageing. 2020 Oct 23;49(6):959-965. doi: 10.1093/ageing/afaa077.
The relationship between sarcopenia and orthostatic hypotension (OH) is unclear.
The aim of the present study was to investigate associations between sarcopenia/sarcopenia severity and OH.
A total of 511 patients attending a geriatric outpatient clinic were included. OH was defined as a decrease in systolic and/or diastolic blood pressure of ≥ 20 mmHg and/or ≥ 10 mmHg, respectively, when one transitions from the supine to an upright position. OH was measured by the Head-up Tilt Table test at 1, 3 and 5 min (OH1, OH3 and OH5, respectively). Sarcopenia and its severity were defined according to the revised European consensus on definition and diagnosis.
The mean age of the sample was 75.40 ± 7.35 years, and 69.9% were female. The prevalence of probable sarcopenia, sarcopenia and severe sarcopenia was 42.2%, 6.06% and 11.1%, respectively. After adjustment for all covariates, systolic OH1, OH1 and systolic OH5 were statistically significantly different between severe sarcopenia and the robust group (odds ratio [OR]: 3.26, confidence interval [CI] 0.98-10.84; P = 0.05 for systolic OH1; OR 4.31, CI 1.31-14.15; P = 0.016 for OH1; OR 4.09, CI 1.01-16.55; P = 0.048 for systolic OH5). Only systolic OH1 was statistically different between the sarcopenia and severe sarcopenia groups (OR 2.64, CI 1.87-8.73; P = 0.012). OH1 and OH5 were statistically significant different between severe sarcopenia and probable sarcopenia groups (P < 0.05); there was no relationship between the robust group and probable sarcopenia (P > 0.05).
There is a close relationship between sarcopenia and severe sarcopenia and OH in older adults. Therefore, when a healthcare practitioner is evaluating an older patient with sarcopenia, OH should also be evaluated, and vice versa.
肌少症与直立性低血压（OH）之间的关系尚不清楚。
本研究旨在探讨肌少症/肌少症严重程度与 OH 之间的关系。
共纳入 511 名在老年门诊就诊的患者。OH 定义为从仰卧位转为直立位时收缩压和/或舒张压下降≥ 20mmHg 和/或≥ 10mmHg。OH 通过仰卧倾斜试验在 1、3 和 5 分钟时（分别为 OH1、OH3 和 OH5）进行测量。根据修订后的欧洲肌少症定义和诊断共识，定义肌少症及其严重程度。
样本的平均年龄为 75.40±7.35 岁，69.9%为女性。可能的肌少症、肌少症和严重肌少症的患病率分别为 42.2%、6.06%和 11.1%。调整所有协变量后，严重肌少症与强壮组之间的收缩压 OH1、OH1 和收缩压 OH5 存在统计学差异（比值比 [OR]：3.26，95%置信区间 [CI]：0.98-10.84；P=0.05 用于收缩压 OH1；OR 4.31，CI 1.31-14.15；P=0.016 用于 OH1；OR 4.09，CI 1.01-16.55；P=0.048 用于收缩压 OH5）。只有收缩压 OH1 在肌少症和严重肌少症组之间存在统计学差异（OR 2.64，CI 1.87-8.73；P=0.012）。严重肌少症和可能的肌少症组之间的 OH1 和 OH5 存在统计学差异（P<0.05）；强壮组与可能的肌少症之间无关系（P>0.05）。
老年人中肌少症与严重肌少症和 OH 密切相关。因此，当医疗保健提供者评估患有肌少症的老年患者时，也应评估 OH，反之亦然。
