Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
Cancer Epidemiology Program, Division of Population Science, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
J Infect Dis. 2021 Feb 13;223(3):441-444. doi: 10.1093/infdis/jiaa385.
Nasopharyngeal carcinoma (NPC) is caused by Epstein-Barr virus (EBV) and is more likely to occur in susceptible families. Whether genetic susceptibility operates through altered EBV control is incompletely understood. We used a NPC risk prediction model based on 14 EBV markers to compare risk score distribution in unaffected members from multiplex families with that in population-based controls. Despite the absence of NPC at the time of antibody measurement, we observed an upward shift in risk score among multiplex family members compared to the general population, consistent with the possibility that genetic factors affect NPC risk through alterations in EBV control.
鼻咽癌（NPC）是由 Epstein-Barr 病毒（EBV）引起的，更容易发生在易感家族中。遗传易感性是否通过改变 EBV 的控制来发挥作用尚不完全清楚。我们使用了一个基于 14 个 EBV 标志物的 NPC 风险预测模型，比较了多基因家族中未受影响成员与基于人群对照者的风险评分分布。尽管在抗体测量时没有 NPC，但我们观察到多基因家族成员的风险评分与普通人群相比有所上升，这表明遗传因素可能通过改变 EBV 的控制来影响 NPC 的风险。
