多发性硬化症患者泌尿系统疾病的管理：现有及新兴疗法综述
Managing Urological Disorders in Multiple Sclerosis Patients: A Review of Available and Emerging Therapies.
作者信息
Bientinesi Riccardo, Gandi Carlo, Bassi PierFrancesco
机构信息
Department of Urology, Catholic University Medical School, Agostino Gemelli Hospital Foundation - IRCCS, Rome, Italy.
出版信息
Int Neurourol J. 2020 Jun;24(2):118-126. doi: 10.5213/inj.2040028.014. Epub 2020 Jun 30.
Abstract
Multiple sclerosis (MS) is a progressive neurological autoimmune disease with a diverse range of urological symptomatology, and most MS patients experience 1 or more moderate to severe urinary symptoms, as well as bladder and/or sexual disorders. Urologists play the director's role in evaluating and treating these patients. Therefore, identifying the proper evaluation tools and the most suitable therapeutic options for specific patients requires a thorough understanding of this disease process.
摘要
多发性硬化症（MS）是一种进行性神经自身免疫性疾病，伴有多种泌尿系统症状，大多数MS患者会出现1种或多种中度至重度泌尿系统症状，以及膀胱和/或性功能障碍。泌尿科医生在评估和治疗这些患者中起主导作用。因此，为特定患者确定合适的评估工具和最合适的治疗方案需要对这种疾病过程有透彻的了解。
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本文引用的文献
1
Lower urinary tract symptoms and sexual dysfunction in men with multiple sclerosis.多发性硬化症男性患者的下尿路症状和性功能障碍。
Clinics (Sao Paulo). 2019 Mar 14;74:e713. doi: 10.6061/clinics/2019/e713.
2
[Ejaculation disorders in multiple sclerosis: Prospective study of 44 patients].
Prog Urol. 2019 Jul;29(7):385-390. doi: 10.1016/j.purol.2019.02.001. Epub 2019 Feb 25.
3
Outcomes following percutaneous tibial nerve stimulation (PTNS) treatment for neurogenic and idiopathic overactive bladder.经皮胫神经刺激（PTNS）治疗神经源性和特发性逼尿肌过度活动症的结果。
Clin Auton Res. 2020 Feb;30(1):61-67. doi: 10.1007/s10286-018-0553-8. Epub 2018 Aug 3.
4
Patient perceived changes in sexual dysfunction after initiation of natalizumab for multiple sclerosis.在开始使用那他珠单抗治疗多发性硬化症后患者察觉到的性功能障碍变化。
Mult Scler J Exp Transl Clin. 2018 Jun 12;4(2):2055217318781989. doi: 10.1177/2055217318781989. eCollection 2018 Apr-Jun.
5
Efficacy and safety of mirabegron for the treatment of neurogenic detrusor overactivity-Prospective, randomized, double-blind, placebo-controlled study.米拉贝隆治疗神经源性逼尿肌过度活动症的疗效和安全性：前瞻性、随机、双盲、安慰剂对照研究。
Neurourol Urodyn. 2018 Sep;37(7):2226-2233. doi: 10.1002/nau.23566. Epub 2018 Mar 31.
6
7
Increased risk of erectile dysfunction in men with multiple sclerosis: an Italian cross-sectional study.多发性硬化症男性勃起功能障碍风险增加：一项意大利横断面研究。
Cent European J Urol. 2017;70(3):289-295. doi: 10.5173/ceju.2017.1380. Epub 2017 Aug 4.
8
THC/CBD oromucosal spray in patients with multiple sclerosis overactive bladder: a pilot prospective study.大麻二酚/大麻酚口腔喷雾剂治疗多发性硬化症伴膀胱过度活动症患者的前瞻性初步研究。
Neurol Sci. 2018 Jan;39(1):97-102. doi: 10.1007/s10072-017-3148-6. Epub 2017 Oct 19.
9
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BJU Int. 2017 Apr;119(4):515-521. doi: 10.1111/bju.13759. Epub 2017 Feb 23.
10
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J Endocrinol Invest. 2017 Mar;40(3):275-279. doi: 10.1007/s40618-016-0557-y. Epub 2016 Oct 17.
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