铜催化的多杂环模块化组装
Copper-Catalyzed Modular Assembly of Polyheterocycles.
作者信息
Wang Qian, Tuinhof Jesse, Mgimpatsang Kumchok C, Kurpiewska Katarzyna, Kalinowska-Tluscik Justyna, Dömling Alexander
机构信息
Department of Drug Design, University of Groningen, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Faculty of Chemistry, Jagiellonian University, 3 Ingardena Street, 30-060 Krakow, Poland.
出版信息
J Org Chem. 2020 Aug 7;85(15):9915-9927. doi: 10.1021/acs.joc.0c01238. Epub 2020 Jul 12.
Easy operation, readily accessible starting materials, and short syntheses of the privileged scaffold indeno[1,2-]isoquinolinone were achieved by an multicomponent reaction (MCR)-based protocol via an ammonia-Ugi-four component reaction (4CR)/copper-catalyzed annulation sequence. The optimization and scope and limitations of this short and general sequence are described. The methodology allows an efficient construction of a wide variety of indenoisoquinolinones in just two steps.
通过基于多组分反应（MCR）的方案，经由氨-Ugi-四组分反应（4CR）/铜催化环化序列，实现了茚并[1,2-]异喹啉酮这种优势骨架的简便操作、起始原料易于获取以及短合成路线。描述了此简短通用序列的优化、适用范围和局限性。该方法仅通过两步就能高效构建多种茚并异喹啉酮。
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