来自链霉菌 CPCC 204980 的具有细胞毒性和抗菌活性的 Cervinomycins C。
Cervinomycins C with cytotoxic and antibacterial activity from Streptomyces sp. CPCC 204980.
机构信息
NHC Key Laboratory of Biotechnology of Antibiotics, CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
出版信息
J Antibiot (Tokyo). 2020 Dec;73(12):812-817. doi: 10.1038/s41429-020-0342-1. Epub 2020 Jul 3.
Polycyclic xanthones are secondary metabolites from actinomycetes and cervinomycin A and B are bioactive 26-membered polycyclic xanthones from Streptomyces sp. CPCC 204980. Herein, we report cervinomycins C (1-4) from the same strain. The structures of 1-4 were determined by 1D- and 2D-NMR, or single-crystal X-ray diffraction. Compounds 1-4 feature the open or loss of A (oxazolidine) ring in their angular polycyclic framework compared with cervinomycin B. Compounds 1-4 showed potent cytotoxicity against human cancer cell lines HCT116 and BxPC-3, with IC at 0.9-801.0 nM and strong anti-Gram-positive bacterial activity.
多环酮类化合物是放线菌的次生代谢产物，而 Cervinomycin A 和 B 则是来自链霉菌 sp. CPCC 204980 的具有生物活性的 26 元多环酮类化合物。在此，我们报告了来自同一菌株的 Cervinomycins C（1-4）。通过 1D 和 2D-NMR，或单晶 X 射线衍射确定了 1-4 的结构。与 Cervinomycin B 相比，化合物 1-4 的角多环骨架中存在 A（恶唑烷）环的开环或缺失。化合物 1-4 对人癌细胞系 HCT116 和 BxPC-3 表现出强烈的细胞毒性，IC 值在 0.9-801.0 nM 之间，对革兰氏阳性菌具有很强的抗菌活性。
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