Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
Department of Biology, Harold Washington City College of Chicago, Chicago, IL, USA.
Anim Sci J. 2020 Jan-Dec;91(1):e13424. doi: 10.1111/asj.13424.
Recent in vitro evidence suggests that the phytol-derived fatty acids, phytanic acid (PA) and pristanic acid (PrA), are components of animal products with the potential to cause both beneficial and harmful effects on human health. In this study, we investigated the in vivo tissue accumulation of PA and PrA and the changes in tissue lipid profiles, using mice fed a phytol-containing diet. After 4 weeks of treatment with a diet containing 1.0% phytol, plasma, adipose tissue, liver, and brain were collected and their lipid profiles were biochemically and gas-chromatographically determined. Dietary phytol caused PA and PrA accumulation in the adipose tissue and liver but not in the brain, and reduced plasma and liver triacylglycerol levels. Phytol intake also decreased the fatty acid concentrations in the adipose tissue, especially polyunsaturated fatty acids such as linoleic acid, but increased the concentrations of these fatty acids in the liver. However, dietary phytol had a low impact on the brain lipid profile. This study suggests that dietary phytol intake caused accumulation of PA and PrA and modified lipid profiles in the adipose tissue and liver, but that the brain is an insusceptible tissue to dietary phytol-induced changes.
最近的体外证据表明，植物衍生的脂肪酸植烷酸（PA）和姥鲛烷酸（PrA）是动物产品的组成部分，有可能对人类健康产生有益和有害的影响。在这项研究中，我们使用喂食含植醇饮食的小鼠，研究了 PA 和 PrA 的体内组织积累情况以及组织脂质谱的变化。在含有 1.0%植醇的饮食治疗 4 周后，收集血浆、脂肪组织、肝脏和大脑，并通过生化和气相色谱法确定其脂质谱。饮食植醇导致脂肪组织和肝脏中 PA 和 PrA 的积累，但在大脑中没有，并且降低了血浆和肝脏三酰甘油水平。植醇的摄入还降低了脂肪组织中脂肪酸的浓度，特别是多不饱和脂肪酸如亚油酸，但增加了肝脏中这些脂肪酸的浓度。然而，饮食植醇对大脑脂质谱的影响较小。这项研究表明，饮食植醇的摄入导致 PA 和 PrA 的积累，并改变了脂肪组织和肝脏中的脂质谱，但大脑是对饮食植醇诱导的变化不易受影响的组织。
