Private Practice, Ferrara, Italy.
Department of Biomedical, Surgical and Dental Sciences University of Milan, 20122 Milan, Italy.
J Biol Regul Homeost Agents. 2020 May-Jun;34(3 Suppl. 1):99-105. DENTAL SUPPLEMENT.
This review aims to address the procedures and indications, required for the application of the mesenchymal stem cells treatment strategy of regenerative dentistry. Mesenchymal stem cells have rarely been used in this field; conversely, experience from other clinical fields and basic research seems to recommend the suitability of this scope of application. We reviewed 31 out of 206 articles on Web of Science, Scopus, PubMed, etc. The main purpose of this paper is a short review of the literature evaluating the application of stem cells in regenerative dentistry, their ability to get a multilineage differentiation and to introduce a safe and useful alternative way of harvesting and selection. The most common derivation of stem cells used for regenerative dentistry is from the adipose tissue. There are conditions in which the levy adipose cannot be easily achieved, or where large amounts of injectables are not needed. For this purpose, the possibility of selecting stromal stem cells directly from the lax subcutaneous connective tissue preferably of the head region would allow a technical simplification and a greater homology in tissues. .
本文旨在探讨间充质干细胞在再生牙科治疗策略中的应用程序和适应证。间充质干细胞在该领域的应用较少；相反，来自其他临床领域和基础研究的经验似乎表明该应用范围是合适的。我们在 Web of Science、Scopus、PubMed 等数据库中检索了 206 篇文章，其中 31 篇符合纳入标准。本文的主要目的是对文献进行简短回顾，评估干细胞在再生牙科中的应用，它们的多谱系分化能力，并介绍一种安全有效的收获和选择方法。用于再生牙科的干细胞最常见的来源是脂肪组织。在某些情况下，很难采集脂肪组织，或者不需要大量的注射剂。为此，直接从头部松弛的皮下结缔组织中选择基质干细胞的可能性，可以简化技术并使组织具有更大的同源性。
