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Evidence of asymptomatic submicroscopic malaria in low transmission areas in Belaga district, Kapit division, Sarawak, Malaysia.马来西亚砂拉越州加帛地区百乐县低传播地区亚临床无症状疟原虫感染的证据。
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2
Absence of Plasmodium inui and Plasmodium cynomolgi, but detection of Plasmodium knowlesi and Plasmodium vivax infections in asymptomatic humans in the Betong division of Sarawak, Malaysian Borneo.在马来西亚婆罗洲的沙捞越州的百乐地区，在无症状的人群中检测到了间日疟原虫和恶性疟原虫感染，但未发现伊蚊疟原虫和食蟹猴疟原虫感染。
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3
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J Infect Dis. 2017 Apr 1;215(7):1148-1155. doi: 10.1093/infdis/jix091.
4
Asymptomatic and Submicroscopic Carriage of Plasmodium knowlesi Malaria in Household and Community Members of Clinical Cases in Sabah, Malaysia.马来西亚沙巴州疟疾病例的家庭和社区成员中诺氏疟原虫疟疾的无症状及亚显微携带情况
J Infect Dis. 2016 Mar 1;213(5):784-7. doi: 10.1093/infdis/jiv475. Epub 2015 Oct 3.
5
High proportion of knowlesi malaria in recent malaria cases in Malaysia.马来西亚近期疟疾病例中诺氏疟原虫疟疾比例较高。
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Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes.将遗传上可操作的疟原虫病原体恶性疟原虫适应于在人红细胞中连续培养。
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A prospective comparative study of knowlesi, falciparum, and vivax malaria in Sabah, Malaysia: high proportion with severe disease from Plasmodium knowlesi and Plasmodium vivax but no mortality with early referral and artesunate therapy.一项在马来西亚沙巴州进行的关于诺氏疟原虫、恶性疟原虫和间日疟原虫的前瞻性对比研究：来自诺氏疟原虫和间日疟原虫的严重疾病比例较高，但如果早期转诊和使用青蒿琥酯治疗则无死亡。
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Molecular epidemiological investigation of Plasmodium knowlesi in humans and macaques in Singapore.新加坡人体和猕猴中疟原虫 knowlesi 的分子流行病学调查。
Vector Borne Zoonotic Dis. 2011 Feb;11(2):131-5. doi: 10.1089/vbz.2010.0024. Epub 2010 Jun 29.
10
Spurious amplification of a Plasmodium vivax small-subunit RNA gene by use of primers currently used to detect P. knowlesi.使用目前用于检测 P. knowlesi 的引物对间日疟原虫小亚基 RNA 基因进行的假阳性扩增。
J Clin Microbiol. 2009 Dec;47(12):4173-5. doi: 10.1128/JCM.00811-09. Epub 2009 Oct 7.

马来西亚半岛高危人群无症状和/或低密度疟疾感染的流行情况。

Prevalence of Asymptomatic and/or Low-Density Malaria Infection among High-Risk Groups in Peninsular Malaysia.

机构信息

1Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

2Vector Borne Disease Sector, Ministry of Health, Putrajaya, Malaysia.

出版信息

Am J Trop Med Hyg. 2020 Sep;103(3):1107-1110. doi: 10.4269/ajtmh.20-0268.

DOI:10.4269/ajtmh.20-0268
PMID:32618263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7470583/
Abstract

Asymptomatic and/or low-density malaria infection has been acknowledged as an obstacle to achieving a malaria-free country. This study aimed to determine the prevalence of asymptomatic and/or low-density malaria infection in previously reported malarious localities using nested PCR in four states, namely, Johor, Pahang, Kelantan, and Selangor, between June 2019 and January 2020. Blood samples ( = 585) were collected and were extracted using a QIAamp blood kit. The DNA was concentrated and subjected to nested PCR. Thin and thick blood smears were examined as well. Of the 585 samples collected, 19 were positive: 10 for , eight for , and one for . Asymptomatic and/or low-density malaria infection is a threat to malaria elimination initiatives. Eliminating countries should develop guidance policy on the importance of low-density malaria infection which includes detection and treatment policy.

摘要

无症状和/或低密度疟疾感染已被认为是实现无疟疾国家的障碍。本研究旨在使用巢式 PCR 确定 2019 年 6 月至 2020 年 1 月在柔佛州、彭亨州、吉兰丹州和雪兰莪州四个州报告的疟疾流行地区无症状和/或低密度疟疾感染的流行率。采集了 585 份血样，并使用 QIAamp 血液试剂盒提取。浓缩 DNA 并进行巢式 PCR。也检查了薄血涂片和厚血涂片。在采集的 585 个样本中，有 19 个呈阳性：10 个为 ，8 个为 ，1 个为 。无症状和/或低密度疟疾感染是消除疟疾倡议的威胁。消除疟疾的国家应制定关于低密度疟疾感染重要性的指导政策，包括检测和治疗政策。