马来西亚半岛高危人群无症状和/或低密度疟疾感染的流行情况。
Prevalence of Asymptomatic and/or Low-Density Malaria Infection among High-Risk Groups in Peninsular Malaysia.
机构信息
1Department of Parasitology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
2Vector Borne Disease Sector, Ministry of Health, Putrajaya, Malaysia.
出版信息
Am J Trop Med Hyg. 2020 Sep;103(3):1107-1110. doi: 10.4269/ajtmh.20-0268.
Abstract
Asymptomatic and/or low-density malaria infection has been acknowledged as an obstacle to achieving a malaria-free country. This study aimed to determine the prevalence of asymptomatic and/or low-density malaria infection in previously reported malarious localities using nested PCR in four states, namely, Johor, Pahang, Kelantan, and Selangor, between June 2019 and January 2020. Blood samples ( = 585) were collected and were extracted using a QIAamp blood kit. The DNA was concentrated and subjected to nested PCR. Thin and thick blood smears were examined as well. Of the 585 samples collected, 19 were positive: 10 for , eight for , and one for . Asymptomatic and/or low-density malaria infection is a threat to malaria elimination initiatives. Eliminating countries should develop guidance policy on the importance of low-density malaria infection which includes detection and treatment policy.
摘要
无症状和/或低密度疟疾感染已被认为是实现无疟疾国家的障碍。本研究旨在使用巢式 PCR 确定 2019 年 6 月至 2020 年 1 月在柔佛州、彭亨州、吉兰丹州和雪兰莪州四个州报告的疟疾流行地区无症状和/或低密度疟疾感染的流行率。采集了 585 份血样，并使用 QIAamp 血液试剂盒提取。浓缩 DNA 并进行巢式 PCR。也检查了薄血涂片和厚血涂片。在采集的 585 个样本中，有 19 个呈阳性：10 个为 ，8 个为 ，1 个为 。无症状和/或低密度疟疾感染是消除疟疾倡议的威胁。消除疟疾的国家应制定关于低密度疟疾感染重要性的指导政策，包括检测和治疗政策。
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